1221973-93-8
1221973-93-8 structure
- Name: BMS-933043
- Chemical Name: N-[6-(1H-Imidazol-1-yl)-4-pyrimidinyl]-4'H-spiro[4-azabicyclo[2.2.2]octane-2,5'-[1,3]oxazol]-2'-amine
- CAS Number: 1221973-93-8
- Molecular Formula: C16H19N7O
- Molecular Weight: 325.368
- Create Date: 2020-01-12 08:30:51
- Modify Date: 2024-09-15 18:21:07
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BMS-933043 is a novel highly selective, potent α7 nAChR partial agonist with binding Ki of 3.3 and 8.1 nM for rat and human α7, respectively; displays high selectivity against other nAChR subtypes (>100-fold) and 5-HT3A receptor (>300-fold); demonstrates in vivo activity in a preclinical model of cognitive impairment, mouse novel object recognition. Schizophrenia Phase 1 Discontinued
| Name | N-[6-(1H-Imidazol-1-yl)-4-pyrimidinyl]-4'H-spiro[4-azabicyclo[2.2.2]octane-2,5'-[1,3]oxazol]-2'-amine |
|---|---|
| Synonyms |
Spiro[1-azabicyclo[2.2.2]octane-3,5'(4'H)-oxazol]-2'-amine, N-[6-(1H-imidazol-1-yl)-4-pyrimidinyl]-
N-[6-(1H-Imidazol-1-yl)-4-pyrimidinyl]-4'H-spiro[4-azabicyclo[2.2.2]octane-2,5'-[1,3]oxazol]-2'-amine |
| Description | BMS-933043 is a novel highly selective, potent α7 nAChR partial agonist with binding Ki of 3.3 and 8.1 nM for rat and human α7, respectively; displays high selectivity against other nAChR subtypes (>100-fold) and 5-HT3A receptor (>300-fold); demonstrates in vivo activity in a preclinical model of cognitive impairment, mouse novel object recognition. Schizophrenia Phase 1 Discontinued |
|---|---|
| References | References 1. King D, et al. ACS Med Chem Lett. 2017 Feb 8;8(3):366-371. 2. Bristow LJ, et al. PLoS One. 2016 Jul 28;11(7):e0159996. 3. Weed MR, et al. PLoS One. 2017 Dec 19;12(12):e0187609. View Related Products by Target nAChR Schizophrenia |
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Boiling Point | 539.3±60.0 °C at 760 mmHg |
| Molecular Formula | C16H19N7O |
| Molecular Weight | 325.368 |
| Flash Point | 279.9±32.9 °C |
| Exact Mass | 325.165100 |
| LogP | 0.27 |
| Vapour Pressure | 0.0±1.4 mmHg at 25°C |
| Index of Refraction | 1.815 |