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  • DC Chemicals Limited
  • China
  • Product Name: Amelparib
  • Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao

1227156-72-0

1227156-72-0 structure
1227156-72-0 structure
  • Name: Amelparib
  • Chemical Name: Amelparib
  • CAS Number: 1227156-72-0
  • Molecular Formula: C19H25N3O3
  • Molecular Weight: 343.420
  • Create Date: 2020-01-12 17:50:49
  • Modify Date: 2024-01-06 18:00:44
  • Amelparib (JPI-289, JPI289) is a novel potent, water soluble PARP-1 inhibitor with IC50 of 18.5 nM, inhibits cellular PAR formation with IC50 of 10.7 nM; does not affect cell viability up to 1 mM in rat cortical neuronal cells; attenuates PARP activity restores ATP and NAD+ levels in oxygen glucose deprived (OGD) rat cortical neurons, reduces apoptosis-associated molecules such as apoptosis inducing factor (AIF), cytochrome C and cleaved caspase-3 in the OGD model; JPI-289 is a potential neuroprotective agent which could be useful as a treatment for acute ischaemic stroke. Stroke Phase 2 Clinical

Name Amelparib
Synonyms R252S84C2I
Benzo[h][1,6]naphthyridin-5(1H)-one, 10-ethoxy-2,3,4,6-tetrahydro-8-(4-morpholinylmethyl)-
Amelparib
10-Ethoxy-8-(4-morpholinylmethyl)-2,3,4,6-tetrahydrobenzo[h][1,6]naphthyridin-5(1H)-one
Description Amelparib (JPI-289, JPI289) is a novel potent, water soluble PARP-1 inhibitor with IC50 of 18.5 nM, inhibits cellular PAR formation with IC50 of 10.7 nM; does not affect cell viability up to 1 mM in rat cortical neuronal cells; attenuates PARP activity restores ATP and NAD+ levels in oxygen glucose deprived (OGD) rat cortical neurons, reduces apoptosis-associated molecules such as apoptosis inducing factor (AIF), cytochrome C and cleaved caspase-3 in the OGD model; JPI-289 is a potential neuroprotective agent which could be useful as a treatment for acute ischaemic stroke. Stroke Phase 2 Clinical
References References 1. Kim Y, et al. Clin Exp Pharmacol Physiol. 2017 Jun;44(6):671-679. 2. Kim Y, et al. Mol Neurobiol. 2018 Jan 30. doi: 10.1007/s12035-018-0910-6. View Related Products by Target PARP Stroke
Density 1.3±0.1 g/cm3
Boiling Point 569.6±50.0 °C at 760 mmHg
Molecular Formula C19H25N3O3
Molecular Weight 343.420
Flash Point 298.3±30.1 °C
Exact Mass 343.189606
LogP 1.04
Vapour Pressure 0.0±1.6 mmHg at 25°C
Index of Refraction 1.624