Amelparib
Modify Date: 2024-01-06 18:00:44
Amelparib structure
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Common Name | Amelparib | ||
|---|---|---|---|---|
| CAS Number | 1227156-72-0 | Molecular Weight | 343.420 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 569.6±50.0 °C at 760 mmHg | |
| Molecular Formula | C19H25N3O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 298.3±30.1 °C | |
Use of AmelparibAmelparib (JPI-289, JPI289) is a novel potent, water soluble PARP-1 inhibitor with IC50 of 18.5 nM, inhibits cellular PAR formation with IC50 of 10.7 nM; does not affect cell viability up to 1 mM in rat cortical neuronal cells; attenuates PARP activity restores ATP and NAD+ levels in oxygen glucose deprived (OGD) rat cortical neurons, reduces apoptosis-associated molecules such as apoptosis inducing factor (AIF), cytochrome C and cleaved caspase-3 in the OGD model; JPI-289 is a potential neuroprotective agent which could be useful as a treatment for acute ischaemic stroke. Stroke Phase 2 Clinical |
| Name | Amelparib |
|---|---|
| Synonym | More Synonyms |
| Description | Amelparib (JPI-289, JPI289) is a novel potent, water soluble PARP-1 inhibitor with IC50 of 18.5 nM, inhibits cellular PAR formation with IC50 of 10.7 nM; does not affect cell viability up to 1 mM in rat cortical neuronal cells; attenuates PARP activity restores ATP and NAD+ levels in oxygen glucose deprived (OGD) rat cortical neurons, reduces apoptosis-associated molecules such as apoptosis inducing factor (AIF), cytochrome C and cleaved caspase-3 in the OGD model; JPI-289 is a potential neuroprotective agent which could be useful as a treatment for acute ischaemic stroke. Stroke Phase 2 Clinical |
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| References | References 1. Kim Y, et al. Clin Exp Pharmacol Physiol. 2017 Jun;44(6):671-679. 2. Kim Y, et al. Mol Neurobiol. 2018 Jan 30. doi: 10.1007/s12035-018-0910-6. View Related Products by Target PARP Stroke |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 569.6±50.0 °C at 760 mmHg |
| Molecular Formula | C19H25N3O3 |
| Molecular Weight | 343.420 |
| Flash Point | 298.3±30.1 °C |
| Exact Mass | 343.189606 |
| LogP | 1.04 |
| Vapour Pressure | 0.0±1.6 mmHg at 25°C |
| Index of Refraction | 1.624 |
| R252S84C2I |
| Benzo[h][1,6]naphthyridin-5(1H)-one, 10-ethoxy-2,3,4,6-tetrahydro-8-(4-morpholinylmethyl)- |
| Amelparib |
| 10-Ethoxy-8-(4-morpholinylmethyl)-2,3,4,6-tetrahydrobenzo[h][1,6]naphthyridin-5(1H)-one |