1256269-87-0

1256269-87-0 structure

Name: SAK 3
Chemical Name: SAK3
CAS Number: 1256269-87-0
Molecular Formula: C₂₀H₂₃N₃O₄
Molecular Weight: 369.414
Catalog: Signaling Pathways Membrane Transporter/Ion Channel Calcium Channel
Create Date: 2020-01-20 07:38:56
Modify Date: 2025-08-27 02:54:20
SAK3 (T-VGCC enhancer SAK3) is a potent, orally acitve enhancer of T-type voltage-gated Ca2+ channel (T-VGCC), enhances CaV3.1 and CaV3.3, but not CaV3.2 activity at concentrations of 0.01-10 nM in neuro2A cells in vitro; significantly enhanced acetylcholine (ACh) release in the hippocampal CA1 region of naïve mice (0.5 mg/kg, p.o.); significantly enhanced hippocampal ACh levels in olfactory-bulbectomized (OBX) mice, rescuing impaired memory-related behaviors.

Name	SAK3
Synonyms	SAK3 Ethyl 8'-methyl-2',4-dioxo-2-(piperidin-1-yl)-2'H-spiro[cyclopent[2]ene-1,3'-imidazo[1,2-a]pyridine]-3-carboxylate 8'-Methyl-2',4-dioxo-2-(1-piperidinyl)-spiro[2-cyclopentene-1,3'(2'H)-imidazo[1,2-a]pyridine]-3-carboxylic acid ethyl ester Spiro[cyclopent-2-ene-1,3'(2'H)-imidazo[1,2-a]pyridine]-3-carboxylic acid, 8'-methyl-2',4-dioxo-2-(1-piperidinyl)-, ethyl ester Ethyl 8'-methyl-2',4-dioxo-2-(1-piperidinyl)-2'H-spiro[cyclopent-2-ene-1,3'-imidazo[1,2-a]pyridine]-3-carboxylate

Description	SAK3 (T-VGCC enhancer SAK3) is a potent, orally acitve enhancer of T-type voltage-gated Ca2+ channel (T-VGCC), enhances CaV3.1 and CaV3.3, but not CaV3.2 activity at concentrations of 0.01-10 nM in neuro2A cells in vitro; significantly enhanced acetylcholine (ACh) release in the hippocampal CA1 region of naïve mice (0.5 mg/kg, p.o.); significantly enhanced hippocampal ACh levels in olfactory-bulbectomized (OBX) mice, rescuing impaired memory-related behaviors.
References	References 1. Yabuki Y, et al. Neuropharmacology. 2017 May 1;117:1-13. 2. Izumi H, et al. Neuroscience. 2018 May 1;377:87-97. 3. Husain N, et al. Pharmacology. 2018;101(5-6):309-321. 4. Wang S, et al. PLoS One. 2018 Dec 20;13(12):e0206986. View Related Products by Target Calcium Channel