1378266-98-8

1378266-98-8 structure

Name: Zifaxaban
Chemical Name: 5-Chloro-N-({(5S)-2-oxo-3-[4-(2-oxo-1(2H)-pyridinyl)phenyl]-1,3-oxazolidin-5-yl}methyl)-2-thiophenecarboxamide
CAS Number: 1378266-98-8
Molecular Formula: C₂₀H₁₆ClN₃O₄S
Molecular Weight: 429.877
Catalog: Signaling Pathways Metabolic Enzyme/Protease Factor Xa
Create Date: 2020-01-20 11:03:55
Modify Date: 2024-05-11 18:22:46
Zifaxaban is a novel, potent, selective, direct and oral factor Xa inhibitor with IC50 of 11.1 nM (human FXa), displays > 10,000-fold selectivity than other serine proteases; also deoes not impair platelet aggregation induced by collagen, adenosine diphosphate (ADP) or arachidonic acid; significantly prolongs clotting time, prothrombin time (PT), and activated partial thromboplastin time (APTT) in the plasma of humans, rabbits, and rats, with a relatively weak effect on thrombin time; strongly suppresses thrombus formation with ED50 values of 3.09 mg/kg in venous thrombosis models in rats.

Name	5-Chloro-N-({(5S)-2-oxo-3-[4-(2-oxo-1(2H)-pyridinyl)phenyl]-1,3-oxazolidin-5-yl}methyl)-2-thiophenecarboxamide
Synonyms	5-Chloro-N-({(5S)-2-oxo-3-[4-(2-oxo-1(2H)-pyridinyl)phenyl]-1,3-oxazolidin-5-yl}methyl)-2-thiophenecarboxamide 2-Thiophenecarboxamide, 5-chloro-N-[[(5S)-2-oxo-3-[4-(2-oxo-1(2H)-pyridinyl)phenyl]-5-oxazolidinyl]methyl]-

Description	Zifaxaban is a novel, potent, selective, direct and oral factor Xa inhibitor with IC50 of 11.1 nM (human FXa), displays > 10,000-fold selectivity than other serine proteases; also deoes not impair platelet aggregation induced by collagen, adenosine diphosphate (ADP) or arachidonic acid; significantly prolongs clotting time, prothrombin time (PT), and activated partial thromboplastin time (APTT) in the plasma of humans, rabbits, and rats, with a relatively weak effect on thrombin time; strongly suppresses thrombus formation with ED50 values of 3.09 mg/kg in venous thrombosis models in rats.
References	References 1. Qiu X, et al. Eur J Pharmacol. 2018 Aug 17. pii: S0014-2999(18)30469-2. View Related Products by Target Factor Xa