1383846-83-0
1383846-83-0 structure
- Name: AZ-4217
- Chemical Name: AZ-4217
- CAS Number: 1383846-83-0
- Molecular Formula: C30H25FN4O
- Molecular Weight: 476.544
- Create Date: 2020-01-11 18:30:50
- Modify Date: 2024-01-05 14:55:35
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AZ-4217 is a potent and selective, orally active, brain-permeable BACE1 inhibitor with IC50 of 160 pM in human SH-SY5Y cells; demonstrates excellent in vivo efficacy, lowers amyloid deposition in 12-month-old Tg2576 mice.
| Name | AZ-4217 |
|---|---|
| Synonyms |
5-[(1R)-3-Amino-4-fluoro-1-{3-[5-(1-propyn-1-yl)-3-pyridinyl]phenyl}-1H-isoindol-1-yl]-1-ethyl-3-methyl-2(1H)-pyridinone
AZ-4217 2(1H)-Pyridinone, 5-[(1R)-3-amino-4-fluoro-1-[3-[5-(1-propyn-1-yl)-3-pyridinyl]phenyl]-1H-isoindol-1-yl]-1-ethyl-3-methyl- |
| Description | AZ-4217 is a potent and selective, orally active, brain-permeable BACE1 inhibitor with IC50 of 160 pM in human SH-SY5Y cells; demonstrates excellent in vivo efficacy, lowers amyloid deposition in 12-month-old Tg2576 mice. |
|---|---|
| References | References 1. Eketjäll S, et al. J Neurosci. 2013 Jun 12;33(24):10075-84. 2. Swahn BM, et al. J Med Chem. 2012 Nov 8;55(21):9346-61. View Related Products by Target Beta-secretase (BACE) |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 732.5±70.0 °C at 760 mmHg |
| Molecular Formula | C30H25FN4O |
| Molecular Weight | 476.544 |
| Flash Point | 396.8±35.7 °C |
| Exact Mass | 476.201233 |
| LogP | 4.30 |
| Vapour Pressure | 0.0±2.4 mmHg at 25°C |
| Index of Refraction | 1.637 |