1391489-32-9
1391489-32-9 structure
- Name: 25CN-NBOH
- Chemical Name: 25CN-NBOH
- CAS Number: 1391489-32-9
- Molecular Formula: C18H20N2O3
- Molecular Weight: 312.363
- Create Date: 2020-01-19 21:09:03
- Modify Date: 2024-01-29 11:44:08
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A potent, highly selective and brain-penetrant 5-HT2A receptor agonist with Ki of 1.1 nM ([3H]ketanserin); >100-fold over 5-HT2CR and 46-fold selectivity over 5-HT2BR; exhibits 30- to 180-fold 5-HT2A/5-HT2C selectivities and 54-fold 5-HT2A/5-HT2B selectivity in inositol phosphate and intracellular Ca2+ mobilization assays; is a superior selective and brain-penetrant 5-HT2A receptor agonist compared with (±)-2,5-dimethoxy-4-iodoamphetamine (DOI).
| Name | 25CN-NBOH |
|---|---|
| Synonyms |
Benzonitrile, 4-[2-[[(2-hydroxyphenyl)methyl]amino]ethyl]-2,5-dimethoxy-
25CN-NBOH 4-{2-[(2-Hydroxybenzyl)amino]ethyl}-2,5-dimethoxybenzonitrile |
| Description | A potent, highly selective and brain-penetrant 5-HT2A receptor agonist with Ki of 1.1 nM ([3H]ketanserin); >100-fold over 5-HT2CR and 46-fold selectivity over 5-HT2BR; exhibits 30- to 180-fold 5-HT2A/5-HT2C selectivities and 54-fold 5-HT2A/5-HT2B selectivity in inositol phosphate and intracellular Ca2+ mobilization assays; is a superior selective and brain-penetrant 5-HT2A receptor agonist compared with (±)-2,5-dimethoxy-4-iodoamphetamine (DOI). |
|---|---|
| References | References 1. Jensen AA, et al. J Pharmacol Exp Ther. 2017 Jun;361(3):441-453. 2. Fantegrossi WE, et al. Psychopharmacology (Berl). 2015 Mar;232(6):1039-47. 3. Halberstadt AL, et al. Neuropharmacology. 2016 Aug;107:364-375. 4. Hansen M, et al. ACS Chem Neurosci. 2014 Mar 19;5(3):243-9. View Related Products by Target 5-HT Receptor |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 508.5±50.0 °C at 760 mmHg |
| Molecular Formula | C18H20N2O3 |
| Molecular Weight | 312.363 |
| Flash Point | 261.3±30.1 °C |
| Exact Mass | 312.147400 |
| LogP | 2.33 |
| Vapour Pressure | 0.0±1.4 mmHg at 25°C |
| Index of Refraction | 1.597 |