1541170-75-5
1541170-75-5 structure
- Name: KH-176
- Chemical Name: KH-176
- CAS Number: 1541170-75-5
- Molecular Formula: C19H28N2O3
- Molecular Weight: 332.437
- Catalog: Research Areas Metabolic Disease
- Create Date: 2020-01-12 16:46:44
- Modify Date: 2024-01-11 16:52:31
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KH-176 (KH176, Sonlicromanol) is a smal molecule ROS-redox modulator, effectively reduces increased cellular ROS levels and protects OXPHOS deficient primary cells against redox perturbation by targeting the Thioredoxin/Peroxiredoxin system; significantly improves rotarod and gait performance and reduces the degeneration of retinal ganglion cells in Ndufs4 -/- mice, shows therapeutic effects in mammalian model of Leigh Disease.
| Name | KH-176 |
|---|---|
| Synonyms |
2H-1-Benzopyran-2-carboxamide, 3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-N-[(3R)-3-piperidinyl]-, (2S)-
KH-176 JCU3O35RDS (2S)-6-Hydroxy-2,5,7,8-tetramethyl-N-[(3R)-3-piperidinyl]-2-chromanecarboxamide |
| Description | KH-176 (KH176, Sonlicromanol) is a smal molecule ROS-redox modulator, effectively reduces increased cellular ROS levels and protects OXPHOS deficient primary cells against redox perturbation by targeting the Thioredoxin/Peroxiredoxin system; significantly improves rotarod and gait performance and reduces the degeneration of retinal ganglion cells in Ndufs4 -/- mice, shows therapeutic effects in mammalian model of Leigh Disease. |
|---|---|
| References | References 1. de Haas R, et al. Sci Rep. 2017 Sep 15;7(1):11733. 2. Koene S, et al. Orphanet J Rare Dis. 2017 Oct 16;12(1):163. 3. Beyrath J, et al. Sci Rep. 2018 Apr 26;8(1):6577. View Related Products by Target Adenosine Receptor |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 570.8±50.0 °C at 760 mmHg |
| Molecular Formula | C19H28N2O3 |
| Molecular Weight | 332.437 |
| Flash Point | 299.0±30.1 °C |
| Exact Mass | 332.209991 |
| LogP | 2.39 |
| Vapour Pressure | 0.0±1.6 mmHg at 25°C |
| Index of Refraction | 1.583 |