1628343-77-0
1628343-77-0 structure
- Name: ARN 726
- Chemical Name: compound 6 [PMID: 25874594]
- CAS Number: 1628343-77-0
- Molecular Formula: C14H24N2O3
- Molecular Weight: 268.352
- Catalog: Research Areas Inflammation/Immunology
- Create Date: 2020-01-12 23:48:12
- Modify Date: 2024-01-21 19:57:31
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ARN726 is a potent, selective, orally bioavailable N-acylethanolamine acid amidase (NAAA) inhibitor with IC50 of 63 nM (r-NAAA) and 27 nM (h-NAAA); shows no interaction with a panel of 28 biologically relevant targets comprising lipid-metabolizing and inflammation-related enzymes; exerts profound anti-inflammatory effects in both mouse models and human macrophages.
| Name | compound 6 [PMID: 25874594] |
|---|---|
| Synonyms |
compound 6 [PMID: 25874594]
Carbamic acid, N-[(3S)-2-oxo-3-azetidinyl]-, 4-cyclohexylbutyl ester 4-Cyclohexylbutyl [(3S)-2-oxo-3-azetidinyl]carbamate |
| Description | ARN726 is a potent, selective, orally bioavailable N-acylethanolamine acid amidase (NAAA) inhibitor with IC50 of 63 nM (r-NAAA) and 27 nM (h-NAAA); shows no interaction with a panel of 28 biologically relevant targets comprising lipid-metabolizing and inflammation-related enzymes; exerts profound anti-inflammatory effects in both mouse models and human macrophages. |
|---|---|
| References | References 1. Ribeiro A, et al. ACS Chem Biol. 2015 Aug 21;10(8):1838-46. 2. Bonezzi FT, et al. J Pharmacol Exp Ther. 2016 Mar;356(3):656-63. View Related Products by Target Other Targets |
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 478.8±34.0 °C at 760 mmHg |
| Molecular Formula | C14H24N2O3 |
| Molecular Weight | 268.352 |
| Flash Point | 243.4±25.7 °C |
| Exact Mass | 268.178680 |
| LogP | 1.88 |
| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
| Index of Refraction | 1.515 |