1661845-86-8
1661845-86-8 structure
- Name: CRT 0105950
- Chemical Name: 4-({5-[3-(2-Chloro-4-methylphenyl)-4-pyridinyl]-1,3-thiazol-2-yl}amino)phenol
- CAS Number: 1661845-86-8
- Molecular Formula: C21H16ClN3OS
- Molecular Weight: 393.889
- Catalog: Signaling Pathways Cell Cycle/DNA Damage LIM Kinase (LIMK)
- Create Date: 2020-01-12 09:53:49
- Modify Date: 2024-01-15 10:29:40
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A novel potent LIMK inhibitor with IC50 of 0.3 nM and 1 nM for LIMK1 and LIMK2, respectively; inhibits cofilin phosphorylation and increase αTubulin acetylation in cells; shows significant sensitivity against 656 cancer cell lines, and rhabdomyosarcoma, neuroblastoma and kidney cancer cells (mean EC50=19.2 uM).
| Name | 4-({5-[3-(2-Chloro-4-methylphenyl)-4-pyridinyl]-1,3-thiazol-2-yl}amino)phenol |
|---|---|
| Synonyms |
Phenol, 4-[[5-[3-(2-chloro-4-methylphenyl)-4-pyridinyl]-2-thiazolyl]amino]-
4-({5-[3-(2-Chloro-4-methylphenyl)-4-pyridinyl]-1,3-thiazol-2-yl}amino)phenol |
| Description | A novel potent LIMK inhibitor with IC50 of 0.3 nM and 1 nM for LIMK1 and LIMK2, respectively; inhibits cofilin phosphorylation and increase αTubulin acetylation in cells; shows significant sensitivity against 656 cancer cell lines, and rhabdomyosarcoma, neuroblastoma and kidney cancer cells (mean EC50=19.2 uM). |
|---|---|
| References | References 1. Mardilovich K, et al. Oncotarget. 2015 Nov 17;6(36):38469-86. 2. Charles MD, et al. J Med Chem. 2015 Oct 22;58(20):8309-13. View Related Products by Target LIM Kinase (LIMK) |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 556.6±60.0 °C at 760 mmHg |
| Molecular Formula | C21H16ClN3OS |
| Molecular Weight | 393.889 |
| Flash Point | 290.4±32.9 °C |
| Exact Mass | 393.070251 |
| LogP | 4.37 |
| Vapour Pressure | 0.0±1.6 mmHg at 25°C |
| Index of Refraction | 1.695 |