CRT 0105950
Modify Date: 2024-01-15 10:29:40
CRT 0105950 structure
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Common Name | CRT 0105950 | ||
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| CAS Number | 1661845-86-8 | Molecular Weight | 393.889 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 556.6±60.0 °C at 760 mmHg | |
| Molecular Formula | C21H16ClN3OS | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 290.4±32.9 °C | |
Use of CRT 0105950A novel potent LIMK inhibitor with IC50 of 0.3 nM and 1 nM for LIMK1 and LIMK2, respectively; inhibits cofilin phosphorylation and increase αTubulin acetylation in cells; shows significant sensitivity against 656 cancer cell lines, and rhabdomyosarcoma, neuroblastoma and kidney cancer cells (mean EC50=19.2 uM). |
| Name | 4-({5-[3-(2-Chloro-4-methylphenyl)-4-pyridinyl]-1,3-thiazol-2-yl}amino)phenol |
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| Synonym | More Synonyms |
| Description | A novel potent LIMK inhibitor with IC50 of 0.3 nM and 1 nM for LIMK1 and LIMK2, respectively; inhibits cofilin phosphorylation and increase αTubulin acetylation in cells; shows significant sensitivity against 656 cancer cell lines, and rhabdomyosarcoma, neuroblastoma and kidney cancer cells (mean EC50=19.2 uM). |
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| References | References 1. Mardilovich K, et al. Oncotarget. 2015 Nov 17;6(36):38469-86. 2. Charles MD, et al. J Med Chem. 2015 Oct 22;58(20):8309-13. View Related Products by Target LIM Kinase (LIMK) |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 556.6±60.0 °C at 760 mmHg |
| Molecular Formula | C21H16ClN3OS |
| Molecular Weight | 393.889 |
| Flash Point | 290.4±32.9 °C |
| Exact Mass | 393.070251 |
| LogP | 4.37 |
| Vapour Pressure | 0.0±1.6 mmHg at 25°C |
| Index of Refraction | 1.695 |
| Phenol, 4-[[5-[3-(2-chloro-4-methylphenyl)-4-pyridinyl]-2-thiazolyl]amino]- |
| 4-({5-[3-(2-Chloro-4-methylphenyl)-4-pyridinyl]-1,3-thiazol-2-yl}amino)phenol |