1808951-93-0
1808951-93-0 structure
- Name: LP 99
- Chemical Name: LP99
- CAS Number: 1808951-93-0
- Molecular Formula: C26H30ClN3O4S
- Molecular Weight: 516.052
- Catalog: Signaling Pathways Epigenetics Epigenetic Reader Domain
- Create Date: 2020-01-12 11:27:51
- Modify Date: 2024-01-08 18:43:03
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LP99 is the first potent and selective BRD7/9 bromodomain inhibitor with Kd of 99 nM for BRD9; inhibits IL‐6 secretion from THP‐1 cells in a dose‐dependent manner; decreases BRET for both BRD7 and BRD9 in both the H3.3 and H4 systems in a dose‐dependent manner, with cellular IC50 values in the low micromolar range for both histones.
| Name | LP99 |
|---|---|
| Synonyms |
1-Propanesulfonamide, N-[(2R,3S)-2-(4-chlorophenyl)-1-(1,2-dihydro-1,4-dimethyl-2-oxo-7-quinolinyl)-6-oxo-3-piperidinyl]-2-methyl-
N-(2R,3S)-2-(4-Chlorophenyl)-1-(1,4-dimethyl-2-oxo-1,2-dihydroquinolin-7-yl)-6-oxopiperidin-3-yl)-2-methylpropane-1-sulfonamide (2R,3S)-LP99 LP99 MFCD28969655 N-[(2R,3S)-2-(4-Chlorophenyl)-1-(1,4-dimethyl-2-oxo-1,2-dihydro-7-quinolinyl)-6-oxo-3-piperidinyl]-2-methyl-1-propanesulfonamide |
| Description | LP99 is the first potent and selective BRD7/9 bromodomain inhibitor with Kd of 99 nM for BRD9; inhibits IL‐6 secretion from THP‐1 cells in a dose‐dependent manner; decreases BRET for both BRD7 and BRD9 in both the H3.3 and H4 systems in a dose‐dependent manner, with cellular IC50 values in the low micromolar range for both histones. |
|---|---|
| References | References 1. Clark PG, et al. Angew Chem Weinheim Bergstr Ger. 2015 May 18;127(21):6315-6319. View Related Products by Target Bromodomain |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 726.6±70.0 °C at 760 mmHg |
| Molecular Formula | C26H30ClN3O4S |
| Molecular Weight | 516.052 |
| Flash Point | 393.2±35.7 °C |
| Exact Mass | 515.164551 |
| LogP | 4.15 |
| Vapour Pressure | 0.0±2.4 mmHg at 25°C |
| Index of Refraction | 1.644 |