1928707-56-5
1928707-56-5 structure
- Name: F-901318
- Chemical Name: olorofim
- CAS Number: 1928707-56-5
- Molecular Formula: C28H27FN6O2
- Molecular Weight: 498.551
- Create Date: 2020-01-12 11:50:50
- Modify Date: 2024-01-05 11:26:01
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A novel antifungal agent that inhibits A. fumigatus DHODH with IC50 of 44 nM; shows little inhibition of human DHODH (>100 uM); displays excellent potency against a broad range of pathogenic filamentous and dimorphic fungi, including Penicillium spp., Coccidiodes immitis, H. capsulatum, Blastomyces dermatitidis, Fusarium spp., and the difficult-to-treat Scedosporium spp. Fungal Infection Phase 2 Clinical
| Name | olorofim |
|---|---|
| Synonyms |
1H-Pyrrole-2-acetamide, N-[4-[4-(5-fluoro-2-pyrimidinyl)-1-piperazinyl]phenyl]-1,5-dimethyl-α-oxo-3-phenyl-
T34SH2H9HI 2-(1,5-Dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-{4-[4-(5-fluoro-2-pyrimidinyl)-1-piperazinyl]phenyl}-2-oxoacetamide olorofim F-901318 |
| Description | A novel antifungal agent that inhibits A. fumigatus DHODH with IC50 of 44 nM; shows little inhibition of human DHODH (>100 uM); displays excellent potency against a broad range of pathogenic filamentous and dimorphic fungi, including Penicillium spp., Coccidiodes immitis, H. capsulatum, Blastomyces dermatitidis, Fusarium spp., and the difficult-to-treat Scedosporium spp. Fungal Infection Phase 2 Clinical |
|---|---|
| References | References 1. Oliver JD, et al. Proc Natl Acad Sci U S A. 2016 Oct 25. pii: 201608304. 2. Wiederhold NP, et al. J Antimicrob Chemother. 2017 Mar 15. doi: 10.1093/jac/dkx065. 3. Buil JB, et al. J Antimicrob Chemother. 2017 Jun 10. doi: 10.1093/jac/dkx177. View Related Products by Target Fungal Fungal Infection |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Molecular Formula | C28H27FN6O2 |
| Molecular Weight | 498.551 |
| Exact Mass | 498.217957 |
| LogP | 3.46 |
| Index of Refraction | 1.660 |