280783-56-4

280783-56-4 structure

Name: Ro 64-6198
Chemical Name: Ro64-6198
CAS Number: 280783-56-4
Molecular Formula: C₂₆H₃₁N₃O
Molecular Weight: 401.544
Catalog: Signaling Pathways GPCR/G Protein Opioid Receptor
Create Date: 2020-01-14 19:22:14
Modify Date: 2024-01-04 10:37:43
Ro 64-6198 is a nonpeptidic, selective, brain-penetrant agonist of nociceptin/orphanin FQ receptor (NOP receptor/ORL1) with pKi of 9.41; displays >100-fold selectivity for ORL1 over other members of opioid receptor family; elicits dose-dependent anxiolytic-like effects in models of distinct types of anxiety states in rata, with no efficient anti-panic-like activity, absence of anticonvulsant properties, and lack of effects on motor performance and cognitive function at anxiolytic doses (0.3 to 3 mg/kg i.p.). Anxiety Discontinued

Name	Ro64-6198
Synonyms	1,3,8-Triazaspiro[4.5]decan-4-one, 8-[(1S,3aS)-2,3,3a,4,5,6-hexahydro-1H-phenalen-1-yl]-1-phenyl- Ro64-6198 8-[(1S,3aS)-2,3,3a,4,5,6-Hexahydro-1H-phenalen-1-yl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one

Description	Ro 64-6198 is a nonpeptidic, selective, brain-penetrant agonist of nociceptin/orphanin FQ receptor (NOP receptor/ORL1) with pKi of 9.41; displays >100-fold selectivity for ORL1 over other members of opioid receptor family; elicits dose-dependent anxiolytic-like effects in models of distinct types of anxiety states in rata, with no efficient anti-panic-like activity, absence of anticonvulsant properties, and lack of effects on motor performance and cognitive function at anxiolytic doses (0.3 to 3 mg/kg i.p.). Anxiety Discontinued
References	References 1. Chang SD, et al. ACS Chem Neurosci. 2015 Dec 16;6(12):1956-64. 2. Saccone PA, et al. J Pharmacol Exp Ther. 2016 Apr;357(1):17-23. 3. Jenck F, et al. Proc Natl Acad Sci U S A. 2000 Apr 25;97(9):4938-43. View Related Products by Target Opioid Receptor Anxiety