313683-81-7
313683-81-7 structure
- Name: Retro 1
- Chemical Name: 7-Bromo-5-phenyl-4-propionyl-1,3,4,5-tetrahydro-2H-1,4-benzodiazepin-2-one
- CAS Number: 313683-81-7
- Molecular Formula: C18H17BrN2O2
- Molecular Weight: 373.244
- Create Date: 2020-01-12 11:39:50
- Modify Date: 2024-01-14 22:50:00
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Retro 1 is the first small molecule inhibitor of plant toxin ricin, protects HeLa cells against Ricin, Stx1 and Stx2, selectively blocks retrograde toxin trafficking at the early endosome-TGN (trans-Golgi network) interface; has no effect on endogenous retrograde cargo proteins; protects mice against ricin challenge.
| Name | 7-Bromo-5-phenyl-4-propionyl-1,3,4,5-tetrahydro-2H-1,4-benzodiazepin-2-one |
|---|---|
| Synonyms |
2H-1,4-Benzodiazepin-2-one, 7-bromo-1,3,4,5-tetrahydro-4-(1-oxopropyl)-5-phenyl-
MFCD00807208 7-Bromo-5-phenyl-4-propionyl-1,3,4,5-tetrahydro-2H-1,4-benzodiazepin-2-one |
| Description | Retro 1 is the first small molecule inhibitor of plant toxin ricin, protects HeLa cells against Ricin, Stx1 and Stx2, selectively blocks retrograde toxin trafficking at the early endosome-TGN (trans-Golgi network) interface; has no effect on endogenous retrograde cargo proteins; protects mice against ricin challenge. |
|---|---|
| References | References 1. Stechmann B, et al. Cell. 2010 Apr 16;141(2):231-42. View Related Products by Target Other Targets |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 544.1±50.0 °C at 760 mmHg |
| Molecular Formula | C18H17BrN2O2 |
| Molecular Weight | 373.244 |
| Flash Point | 282.9±30.1 °C |
| Exact Mass | 372.047333 |
| LogP | 3.35 |
| Vapour Pressure | 0.0±1.5 mmHg at 25°C |
| Index of Refraction | 1.604 |