Retro 1

Modify Date: 2024-01-14 22:50:00

Retro 1 Structure
Retro 1 structure
Common Name Retro 1
CAS Number 313683-81-7 Molecular Weight 373.244
Density 1.4±0.1 g/cm3 Boiling Point 544.1±50.0 °C at 760 mmHg
Molecular Formula C18H17BrN2O2 Melting Point N/A
MSDS N/A Flash Point 282.9±30.1 °C

 Use of Retro 1


Retro 1 is the first small molecule inhibitor of plant toxin ricin, protects HeLa cells against Ricin, Stx1 and Stx2, selectively blocks retrograde toxin trafficking at the early endosome-TGN (trans-Golgi network) interface; has no effect on endogenous retrograde cargo proteins; protects mice against ricin challenge.

 Names

Name 7-Bromo-5-phenyl-4-propionyl-1,3,4,5-tetrahydro-2H-1,4-benzodiazepin-2-one
Synonym More Synonyms

 Retro 1 Biological Activity

Description Retro 1 is the first small molecule inhibitor of plant toxin ricin, protects HeLa cells against Ricin, Stx1 and Stx2, selectively blocks retrograde toxin trafficking at the early endosome-TGN (trans-Golgi network) interface; has no effect on endogenous retrograde cargo proteins; protects mice against ricin challenge.
References References 1. Stechmann B, et al. Cell. 2010 Apr 16;141(2):231-42. View Related Products by Target Other Targets

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 544.1±50.0 °C at 760 mmHg
Molecular Formula C18H17BrN2O2
Molecular Weight 373.244
Flash Point 282.9±30.1 °C
Exact Mass 372.047333
LogP 3.35
Vapour Pressure 0.0±1.5 mmHg at 25°C
Index of Refraction 1.604

 Synonyms

2H-1,4-Benzodiazepin-2-one, 7-bromo-1,3,4,5-tetrahydro-4-(1-oxopropyl)-5-phenyl-
MFCD00807208
7-Bromo-5-phenyl-4-propionyl-1,3,4,5-tetrahydro-2H-1,4-benzodiazepin-2-one
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