410074-73-6
410074-73-6 structure
- Name: Amitifadine
- Chemical Name: Amitifadine
- CAS Number: 410074-73-6
- Molecular Formula: C11H11Cl2N
- Molecular Weight: 228.118
- Create Date: 2020-01-12 00:01:50
- Modify Date: 2024-04-02 21:54:26
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A triple monoamine reuptake inhibitor, inhibits the reuptake of 5-HT, norepinephrine and dopamine in HEK 293 cells with IC50 of 12, 23 and 96 nM, respectively; reduces the duration of immobility in the forced swim test in rats with an oral minimum effective dose (MED) of 5 mg/kg. Depression Phase 3 Clinical
| Name | Amitifadine |
|---|---|
| Synonyms |
EB-1010
(5S)-5-(3,4-dichlorocyclohexa-2,4-dien-1-yl)bicyclo[3.1.0]hexane (1R,5S)-1-(3,4-Dichlorophenyl)-3-azabicyclo[3.1.0]hexane DOV-21,947 GE0J375F8F Amitifadine 5W2YA6F455 3-Azabicyclo[3.1.0]hexane, 1-(3,4-dichlorophenyl)-, (1R,5S)- UNII:5W2YA6F455 |
| Description | A triple monoamine reuptake inhibitor, inhibits the reuptake of 5-HT, norepinephrine and dopamine in HEK 293 cells with IC50 of 12, 23 and 96 nM, respectively; reduces the duration of immobility in the forced swim test in rats with an oral minimum effective dose (MED) of 5 mg/kg. Depression Phase 3 Clinical |
|---|---|
| References | References 1. Skolnick P, et al. Eur J Pharmacol. 2003 Feb 14;461(2-3):99-104. 2. Warnock KT, et al. Pharmacol Biochem Behav. 2012 Nov;103(1):111-8. View Related Products by Target Monoamine Transporter Depression |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 324.4±37.0 °C at 760 mmHg |
| Molecular Formula | C11H11Cl2N |
| Molecular Weight | 228.118 |
| Flash Point | 150.0±26.5 °C |
| Exact Mass | 227.026855 |
| LogP | 2.57 |
| Vapour Pressure | 0.0±0.7 mmHg at 25°C |
| Index of Refraction | 1.622 |