503468-03-9

503468-03-9 structure

Name: NU-7163
Chemical Name: 2-(2-methylmorpholin-4-yl)benzo(h)chromen-4-one
CAS Number: 503468-03-9
Molecular Formula: C₁₈H₁₇NO₃
Molecular Weight: 295.332
Create Date: 2020-01-11 19:51:50
Modify Date: 2024-01-21 11:59:00
A poten and selective, ATP-competitive DNA-PK inhibitor with IC50 of 0.19 uM, Ki of 24 nM; exhibits selectivity for DNA-PK versus related enzymes ATM, ATR, mTOR, and p110α; sensitizes the HeLa cells to the cytotoxic effects of ionizing radiation in vitro.

Name	2-(2-methylmorpholin-4-yl)benzo(h)chromen-4-one
Synonyms	2-(2-methylmorpholin-4-yl)-4H-benzo[h]chromen-4-one 4H-Naphtho[1,2-b]pyran-4-one, 2-(2-methyl-4-morpholinyl)- 2-(2-Methyl-4-morpholinyl)-4H-benzo[h]chromen-4-one 2-(2-methylmorpholin-4-yl)benzo(h)chromen-4-one

Description	A poten and selective, ATP-competitive DNA-PK inhibitor with IC50 of 0.19 uM, Ki of 24 nM; exhibits selectivity for DNA-PK versus related enzymes ATM, ATR, mTOR, and p110α; sensitizes the HeLa cells to the cytotoxic effects of ionizing radiation in vitro.
References	References 1. Griffin RJ, et al. J Med Chem. 2005 Jan 27;48(2):569-85. View Related Products by Target DNA-PK