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  • DC Chemicals Limited
  • China
  • Product Name: GL-1196
  • Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao

591242-70-5

591242-70-5 structure
591242-70-5 structure
  • Name: GL-1196
  • Chemical Name: 2-{[(4-Chlorophenyl)(1,1-dioxido-1,2-benzothiazol-3-yl)amino]methyl}phenol
  • CAS Number: 591242-70-5
  • Molecular Formula: C20H15ClN2O3S
  • Molecular Weight: 398.863
  • Create Date: 2020-01-19 21:46:56
  • Modify Date: 2024-01-09 18:59:17
  • GL-1196 is a PAK4 inhibitor that effectively suppresses the proliferation of human gastric cancer cells through downregulation of PAK4/c-Src/EGFR/cyclinD1 pathway and CDK4/6 expression; prominently inhibits the invasion of human gastric cancer cells in parallel with blockage of the PAK4/LIMK1/cofilin pathway; also inhibits the formation of filopodia and induced cell elongation in SGC7901 and BGC823 cells.

Name 2-{[(4-Chlorophenyl)(1,1-dioxido-1,2-benzothiazol-3-yl)amino]methyl}phenol
Synonyms Phenol, 2-[[(4-chlorophenyl)(1,1-dioxido-1,2-benzisothiazol-3-yl)amino]methyl]-
2-{[(4-Chlorophenyl)(1,1-dioxido-1,2-benzothiazol-3-yl)amino]methyl}phenol
MFCD04084648
Description GL-1196 is a PAK4 inhibitor that effectively suppresses the proliferation of human gastric cancer cells through downregulation of PAK4/c-Src/EGFR/cyclinD1 pathway and CDK4/6 expression; prominently inhibits the invasion of human gastric cancer cells in parallel with blockage of the PAK4/LIMK1/cofilin pathway; also inhibits the formation of filopodia and induced cell elongation in SGC7901 and BGC823 cells.
References References 1. Zhang J, et al. Int J Mol Sci. 2016 Apr 11;17(4):470. View Related Products by Target p21-activated Kinase (PAK)
Density 1.4±0.1 g/cm3
Boiling Point 626.4±65.0 °C at 760 mmHg
Molecular Formula C20H15ClN2O3S
Molecular Weight 398.863
Flash Point 332.6±34.3 °C
Exact Mass 398.049194
LogP 4.01
Vapour Pressure 0.0±1.9 mmHg at 25°C
Index of Refraction 1.679