591242-70-5
591242-70-5 structure
- Name: GL-1196
- Chemical Name: 2-{[(4-Chlorophenyl)(1,1-dioxido-1,2-benzothiazol-3-yl)amino]methyl}phenol
- CAS Number: 591242-70-5
- Molecular Formula: C20H15ClN2O3S
- Molecular Weight: 398.863
- Create Date: 2020-01-19 21:46:56
- Modify Date: 2024-01-09 18:59:17
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GL-1196 is a PAK4 inhibitor that effectively suppresses the proliferation of human gastric cancer cells through downregulation of PAK4/c-Src/EGFR/cyclinD1 pathway and CDK4/6 expression; prominently inhibits the invasion of human gastric cancer cells in parallel with blockage of the PAK4/LIMK1/cofilin pathway; also inhibits the formation of filopodia and induced cell elongation in SGC7901 and BGC823 cells.
| Name | 2-{[(4-Chlorophenyl)(1,1-dioxido-1,2-benzothiazol-3-yl)amino]methyl}phenol |
|---|---|
| Synonyms |
Phenol, 2-[[(4-chlorophenyl)(1,1-dioxido-1,2-benzisothiazol-3-yl)amino]methyl]-
2-{[(4-Chlorophenyl)(1,1-dioxido-1,2-benzothiazol-3-yl)amino]methyl}phenol MFCD04084648 |
| Description | GL-1196 is a PAK4 inhibitor that effectively suppresses the proliferation of human gastric cancer cells through downregulation of PAK4/c-Src/EGFR/cyclinD1 pathway and CDK4/6 expression; prominently inhibits the invasion of human gastric cancer cells in parallel with blockage of the PAK4/LIMK1/cofilin pathway; also inhibits the formation of filopodia and induced cell elongation in SGC7901 and BGC823 cells. |
|---|---|
| References | References 1. Zhang J, et al. Int J Mol Sci. 2016 Apr 11;17(4):470. View Related Products by Target p21-activated Kinase (PAK) |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 626.4±65.0 °C at 760 mmHg |
| Molecular Formula | C20H15ClN2O3S |
| Molecular Weight | 398.863 |
| Flash Point | 332.6±34.3 °C |
| Exact Mass | 398.049194 |
| LogP | 4.01 |
| Vapour Pressure | 0.0±1.9 mmHg at 25°C |
| Index of Refraction | 1.679 |