890605-54-6
890605-54-6 structure
- Name: Heclin
- Chemical Name: Heclin
- CAS Number: 890605-54-6
- Molecular Formula: C17H17NO3
- Molecular Weight: 283.322
- Catalog: Signaling Pathways Metabolic Enzyme/Protease E1/E2/E3 Enzyme
- Create Date: 2020-01-12 11:04:26
- Modify Date: 2024-01-09 18:12:33
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A small molecule inhibitor of HECT-type ubiquitin ligase with IC50 of 6.8/6.3/6.9 uM for Smurf2/Nedd4/WWP1, respectively; does not block E2 binding but causes a conformational change that results in oxidation of the active site Cys; is active against a range of HECT ligases but does not perturb the ubiquitin system more generally.
| Name | Heclin |
|---|---|
| Synonyms |
Heclin
2-Propenamide, N-(4-acetylphenyl)-3-(5-ethyl-2-furanyl)-, (2E)- (2E)-N-(4-Acetylphenyl)-3-(5-ethyl-2-furyl)acrylamide N-(4-Acetylphenyl)-3-(5-ethyl-2-furanyl)-2-propenamide |
| Description | A small molecule inhibitor of HECT-type ubiquitin ligase with IC50 of 6.8/6.3/6.9 uM for Smurf2/Nedd4/WWP1, respectively; does not block E2 binding but causes a conformational change that results in oxidation of the active site Cys; is active against a range of HECT ligases but does not perturb the ubiquitin system more generally. |
|---|---|
| References | References 1. Mund T, et al. Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):16736-41. View Related Products by Target E3 Ubiquitin Ligase |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 495.4±45.0 °C at 760 mmHg |
| Molecular Formula | C17H17NO3 |
| Molecular Weight | 283.322 |
| Flash Point | 253.4±28.7 °C |
| Exact Mass | 283.120850 |
| LogP | 4.22 |
| Vapour Pressure | 0.0±1.3 mmHg at 25°C |
| Index of Refraction | 1.615 |
| Storage condition | -20°C |
| RIDADR | NONH for all modes of transport |
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