908568-01-4

908568-01-4 structure

Name: Inflachromene
Chemical Name: Inflachromene
CAS Number: 908568-01-4
Molecular Formula: C₂₁H₁₉N₃O₄
Molecular Weight: 377.393
Catalog: Research Areas Inflammation/Immunology
Create Date: 2020-01-12 07:05:50
Modify Date: 2024-10-06 02:06:13
Inflachromene (ICM) is a microglial inhibitor with anti-inflammatory effects, directly binds high mobility group protein 1 (HMGB1) and HMGB2 and reduces their cytoplasmic accumulation in microglial cells; blocks the sequential processes of cytoplasmic localization and extracellular release of HMGBs by perturbing its post-translational modification; effectively downregulates proinflammatory functions of HMGB and reduces neuronal damage in vivo.

Name	Inflachromene
Synonyms	Inflachromene 1H,7H-[1]Benzopyrano[4,3-c][1,2,4]triazolo[1,2-a]pyridazine-1,3(2H)-dione, 5,12b-dihydro-10-hydroxy-7,7-dimethyl-2-phenyl- 10-Hydroxy-7,7-dimethyl-2-phenyl-5,12b-dihydro-1H,7H-chromeno[4,3-c][1,2,4]triazolo[1,2-a]pyridazine-1,3(2H)-dione

Description	Inflachromene (ICM) is a microglial inhibitor with anti-inflammatory effects, directly binds high mobility group protein 1 (HMGB1) and HMGB2 and reduces their cytoplasmic accumulation in microglial cells; blocks the sequential processes of cytoplasmic localization and extracellular release of HMGBs by perturbing its post-translational modification; effectively downregulates proinflammatory functions of HMGB and reduces neuronal damage in vivo.
References	References 1. Lee S, et al. Nat Chem Biol. 2014 Dec;10(12):1055-60. 2. Cho W, et al. J Med Chem. 2017 Jan 12;60(1):170-179. View Related Products by Target Other Targets