924866-33-1
924866-33-1 structure
- Name: FPND
- Chemical Name: FPMINT
- CAS Number: 924866-33-1
- Molecular Formula: C24H24FN7
- Molecular Weight: 429.493
- Create Date: 2020-01-11 19:55:24
- Modify Date: 2023-01-11 19:37:19
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A novel specific ROCK1 kinase inhibitor with IC50 of 11.2 uM, without inhibitory activity against ROCK2; prevents atorvastatin-induced cerebral hemorrhage in zebrafish embryos (IC50=17.49 uM), by enhancing endothelial cell-cell junctions through inhibiting the ROCK-mediated VE-cadherin signaling pathway.
| Name | FPMINT |
|---|---|
| Synonyms |
6-{[4-(2-Fluorophenyl)-1-piperazinyl]methyl}-N-(1-naphthyl)-1,3,5-triazine-2,4-diamine
6-[[4-(2-Fluorophenyl)-1-piperazinyl]methyl]-N2-1-naphthalenyl-1,3,5-triazine-2,4-diamine FPMINT 6-{[4-(2-Fluorophenyl)piperazin-1-yl]methyl}-N-(1-naphthyl)-1,3,5-triazine-2,4-diamine 1,3,5-Triazine-2,4-diamine, 6-[[4-(2-fluorophenyl)-1-piperazinyl]methyl]-N2-1-naphthalenyl- 4-((4-(2-Fluorophenyl)piperazin-1-yl)methyl)-6-imino-N-(naphthalen-1-yl)-1,3,5-triazin-2-amine |
| Description | A novel specific ROCK1 kinase inhibitor with IC50 of 11.2 uM, without inhibitory activity against ROCK2; prevents atorvastatin-induced cerebral hemorrhage in zebrafish embryos (IC50=17.49 uM), by enhancing endothelial cell-cell junctions through inhibiting the ROCK-mediated VE-cadherin signaling pathway. |
|---|---|
| References | References 1. Li S, et al. Cell Death Discov. 2017 Aug 21;3:17051. View Related Products by Target ROCK |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 680.3±65.0 °C at 760 mmHg |
| Molecular Formula | C24H24FN7 |
| Molecular Weight | 429.493 |
| Flash Point | 365.2±34.3 °C |
| Exact Mass | 429.207733 |
| LogP | 3.57 |
| Vapour Pressure | 0.0±2.1 mmHg at 25°C |
| Index of Refraction | 1.717 |