942137-41-9
942137-41-9 structure
- Name: AZD 1678
- Chemical Name: 2,3-Dichloro-N-(5-fluoro-3-methoxy-2-pyrazinyl)benzenesulfonamide
- CAS Number: 942137-41-9
- Molecular Formula: C11H8Cl2FN3O3S
- Molecular Weight: 352.169
- Catalog: Signaling Pathways GPCR/G Protein CCR
- Create Date: 2020-01-12 05:45:29
- Modify Date: 2024-04-05 22:17:33
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AZD 1678 is a potent, selective orally bioavailable CCR4 receptor antagonist with pIC50 of 8.6 for hCCR4, pIC50 of 9.0 for rCCR4; shows no significant activity against a panel of chemokine receptors (CXCR1, CXCR2, CCR1, CCR2b, CCR5, CCR7, CCR8; inactive at 10 uM); inhibits Th2 cell CCL22 driven chemotaxis in 0.3% HSA with pIC50 of 6.8. Asthma Phase 1 Clinical
| Name | 2,3-Dichloro-N-(5-fluoro-3-methoxy-2-pyrazinyl)benzenesulfonamide |
|---|---|
| Synonyms |
2,3-Dichloro-N-(5-fluoro-3-methoxy-2-pyrazinyl)benzenesulfonamide
MFCD28975034 Benzenesulfonamide, 2,3-dichloro-N-(5-fluoro-3-methoxy-2-pyrazinyl)- |
| Description | AZD 1678 is a potent, selective orally bioavailable CCR4 receptor antagonist with pIC50 of 8.6 for hCCR4, pIC50 of 9.0 for rCCR4; shows no significant activity against a panel of chemokine receptors (CXCR1, CXCR2, CCR1, CCR2b, CCR5, CCR7, CCR8; inactive at 10 uM); inhibits Th2 cell CCL22 driven chemotaxis in 0.3% HSA with pIC50 of 6.8. Asthma Phase 1 Clinical |
|---|---|
| References | References 1. Kindon N, et al. ACS Med Chem Lett. 2017 Sep 1;8(9):981-986. View Related Products by Target Chemokine Receptor (CCR and CXCR) Asthma |
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Boiling Point | 469.8±55.0 °C at 760 mmHg |
| Molecular Formula | C11H8Cl2FN3O3S |
| Molecular Weight | 352.169 |
| Flash Point | 237.9±31.5 °C |
| Exact Mass | 350.964752 |
| LogP | 3.86 |
| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
| Index of Refraction | 1.614 |