1141768-04-8
1141768-04-8 structure
- Name: PVZB-1194
- Chemical Name: 3'-Fluoro-4'-(trifluoromethyl)-4-biphenylsulfonamide
- CAS Number: 1141768-04-8
- Molecular Formula: C13H9F4NO2S
- Molecular Weight: 319.275
- Catalog: Signaling Pathways Cell Cycle/DNA Damage Kinesin
- Create Date: 2020-01-11 22:01:49
- Modify Date: 2024-02-03 11:25:54
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PVZB-1194 is a bis(hetero)aryl derivative that inhibits kinesin spindle protein (KSP) ATPase witn IC50 of 0.12 uM; inhibits HeLa cell proliferation with IC50 of 5.5 uM; potently inhibits KSP in a microruble dependent manner and induces a monoastral phenotype to arrest mitotic progression, abnormal KSP localization.
| Name | 3'-Fluoro-4'-(trifluoromethyl)-4-biphenylsulfonamide |
|---|---|
| Synonyms |
3'-Fluoro-4'-(trifluoromethyl)-4-biphenylsulfonamide
[1,1'-Biphenyl]-4-sulfonamide, 3'-fluoro-4'-(trifluoromethyl)- 3'-Fluoro-4'-(Trifluoromethyl)biphenyl-4-Sulfonamide |
| Description | PVZB-1194 is a bis(hetero)aryl derivative that inhibits kinesin spindle protein (KSP) ATPase witn IC50 of 0.12 uM; inhibits HeLa cell proliferation with IC50 of 5.5 uM; potently inhibits KSP in a microruble dependent manner and induces a monoastral phenotype to arrest mitotic progression, abnormal KSP localization. |
|---|---|
| References | References 1. Matsuno K, et al. Bioorg Med Chem Lett. 2009 Feb 15;19(4):1058-61. 2. Yokoyama H, et al. ACS Chem Biol. 2015 Apr 17;10(4):1128-36. View Related Products by Target Kinesin |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 417.0±55.0 °C at 760 mmHg |
| Molecular Formula | C13H9F4NO2S |
| Molecular Weight | 319.275 |
| Flash Point | 206.0±31.5 °C |
| Exact Mass | 319.029022 |
| LogP | 3.26 |
| Vapour Pressure | 0.0±1.0 mmHg at 25°C |
| Index of Refraction | 1.536 |