PVZB-1194
Modify Date: 2024-02-03 11:25:54
PVZB-1194 structure
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Common Name | PVZB-1194 | ||
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| CAS Number | 1141768-04-8 | Molecular Weight | 319.275 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 417.0±55.0 °C at 760 mmHg | |
| Molecular Formula | C13H9F4NO2S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 206.0±31.5 °C | |
Use of PVZB-1194PVZB-1194 is a bis(hetero)aryl derivative that inhibits kinesin spindle protein (KSP) ATPase witn IC50 of 0.12 uM; inhibits HeLa cell proliferation with IC50 of 5.5 uM; potently inhibits KSP in a microruble dependent manner and induces a monoastral phenotype to arrest mitotic progression, abnormal KSP localization. |
| Name | 3'-Fluoro-4'-(trifluoromethyl)-4-biphenylsulfonamide |
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| Synonym | More Synonyms |
| Description | PVZB-1194 is a bis(hetero)aryl derivative that inhibits kinesin spindle protein (KSP) ATPase witn IC50 of 0.12 uM; inhibits HeLa cell proliferation with IC50 of 5.5 uM; potently inhibits KSP in a microruble dependent manner and induces a monoastral phenotype to arrest mitotic progression, abnormal KSP localization. |
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| References | References 1. Matsuno K, et al. Bioorg Med Chem Lett. 2009 Feb 15;19(4):1058-61. 2. Yokoyama H, et al. ACS Chem Biol. 2015 Apr 17;10(4):1128-36. View Related Products by Target Kinesin |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 417.0±55.0 °C at 760 mmHg |
| Molecular Formula | C13H9F4NO2S |
| Molecular Weight | 319.275 |
| Flash Point | 206.0±31.5 °C |
| Exact Mass | 319.029022 |
| LogP | 3.26 |
| Vapour Pressure | 0.0±1.0 mmHg at 25°C |
| Index of Refraction | 1.536 |
| 3'-Fluoro-4'-(trifluoromethyl)-4-biphenylsulfonamide |
| [1,1'-Biphenyl]-4-sulfonamide, 3'-fluoro-4'-(trifluoromethyl)- |
| 3'-Fluoro-4'-(Trifluoromethyl)biphenyl-4-Sulfonamide |