1287205-42-8

1287205-42-8 structure

Name: 2-PCCA
Chemical Name: compound 2 [PMID: 24793972]
CAS Number: 1287205-42-8
Molecular Formula: C₃₀H₃₇N₃O
Molecular Weight: 455.634
Create Date: 2020-01-12 12:38:49
Modify Date: 2022-11-21 17:42:28
A potent, selective agonist of the orphan GPR88 receptor with EC50 of 877 nM; inhibits isoproterenol-stimulated cAMP accumulation in a concentration-dependent manner in cells expressing GPR88 through a Gαi-coupled pathway; dose-dependently decreases the locomotor activity in rats at 0.1-3.2mg/kg, also decreases methamphetamine-induced hyperactivity combined with methamphetamine; does not alter the behavioral effects of methamphetamine in rats alone.

Name	compound 2 [PMID: 24793972]
Synonyms	Cyclopropanecarboxamide, N-[(2S,3S)-2-amino-3-methylpentyl]-N-(4'-propyl[1,1'-biphenyl]-4-yl)-2-(2-pyridinyl)-, (1R,2R)- compound 2 [PMID: 24793972] (1R,2R)-N-[(2S,3S)-2-Amino-3-methylpentyl]-N-(4'-propyl-4-biphenylyl)-2-(2-pyridinyl)cyclopropanecarboxamide

Description	A potent, selective agonist of the orphan GPR88 receptor with EC50 of 877 nM; inhibits isoproterenol-stimulated cAMP accumulation in a concentration-dependent manner in cells expressing GPR88 through a Gαi-coupled pathway; dose-dependently decreases the locomotor activity in rats at 0.1-3.2mg/kg, also decreases methamphetamine-induced hyperactivity combined with methamphetamine; does not alter the behavioral effects of methamphetamine in rats alone.
References	References 1. Li JX, et al. Eur J Pharmacol. 2013 Jan 5;698(1-3):272-7. 2. Jin C, et al. ACS Chem Neurosci. 2014 Jul 16;5(7):576-87. 3. Jin C, et al. ACS Chem Neurosci. 2016 Oct 19;7(10):1418-1432. View Related Products by Target GPR88