1334312-52-5
1334312-52-5 structure
- Name: MK-8325
- Chemical Name: Methyl [(2S)-1-{(2S)-4,4-difluoro-2-[5-(4-{2-[(5R)-1-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}-3,3-dimethyl-1,3-azasilolidin-5-yl]-1H-naphtho[1,2-d]imidazol-7-yl}phenyl)-1H-imidazol-2-yl]-1-pyrrolidinyl}-3-methyl-1-oxo-2-butanyl]carbamate
- CAS Number: 1334312-52-5
- Molecular Formula: C43H52F2N8O6Si
- Molecular Weight: 843.005
- Create Date: 2020-01-20 12:13:56
- Modify Date: 2024-01-11 18:26:32
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MK-8325 is a potent, selective pan-genotype HCV NS5A inhibitor with IC50 of 15, 1 and 3 pM for GT1a, GT1b and GT2a, respectively; also demonstrates potencies comparable to MK-4882 against a panel of mutants in both the GT1a and GT1b backgrounds (GT1a M28V IC50=0.1 nM); demonstrates no cell toxicity with a CC50 >25 uM against Huh-7 replicon cells. HCV Infection Phase 1 Clinical
| Name | Methyl [(2S)-1-{(2S)-4,4-difluoro-2-[5-(4-{2-[(5R)-1-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}-3,3-dimethyl-1,3-azasilolidin-5-yl]-1H-naphtho[1,2-d]imidazol-7-yl}phenyl)-1H-imidazol-2-yl]-1-pyrrolidinyl}-3-methyl-1-oxo-2-butanyl]carbamate |
|---|---|
| Synonyms |
Carbamic acid, N-[(1S)-1-[[(2S)-4,4-difluoro-2-[5-[4-[2-[(5R)-1-[(2S)-2-[(methoxycarbonyl)amino]-3-methyl-1-oxobutyl]-3,3-dimethyl-1-aza-3-silacyclopent-5-yl]-1H-naphth[1,2-d]imidazol-7-yl]phenyl]-1H-imidazol-2-yl]-1-pyrrolidinyl]carbonyl]-2-methylpropyl]-, methyl ester
Methyl [(2S)-1-{(2S)-4,4-difluoro-2-[5-(4-{2-[(5R)-1-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}-3,3-dimethyl-1,3-azasilolidin-5-yl]-1H-naphtho[1,2-d]imidazol-7-yl}phenyl)-1H-imidazol-2-yl]-1-pyrrolidinyl}-3-methyl-1-oxo-2-butanyl]carbamate |
| Description | MK-8325 is a potent, selective pan-genotype HCV NS5A inhibitor with IC50 of 15, 1 and 3 pM for GT1a, GT1b and GT2a, respectively; also demonstrates potencies comparable to MK-4882 against a panel of mutants in both the GT1a and GT1b backgrounds (GT1a M28V IC50=0.1 nM); demonstrates no cell toxicity with a CC50 >25 uM against Huh-7 replicon cells. HCV Infection Phase 1 Clinical |
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| References | References 1. Nair AG, et al. Bioorg Med Chem Lett. 2018 Mar 20. pii: S0960-894X(18)30242-7. View Related Products by Target HCV HCV Infection |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 1073.1±65.0 °C at 760 mmHg |
| Molecular Formula | C43H52F2N8O6Si |
| Molecular Weight | 843.005 |
| Flash Point | 602.8±34.3 °C |
| Exact Mass | 842.374695 |
| LogP | 6.49 |
| Vapour Pressure | 0.0±0.3 mmHg at 25°C |
| Index of Refraction | 1.636 |