1351930-95-4

1351930-95-4 structure

Name: GWJ-A-23
Chemical Name: Disodium [4-(decanoylamino)benzyl]phosphonate
CAS Number: 1351930-95-4
Molecular Formula: C₁₇H₂₈NO₄P
Molecular Weight: 385.346
Create Date: 2020-01-11 12:24:02
Modify Date: 2024-02-22 09:33:30
GWJ-A-23 (GWJ-23, GWJ23) is a potent, selective autotaxin inhibitor with Ki of 18 nM, an analog of the known ATX inhibitor S32826 and has improved aqueous solubility compared with the parent compound; reduces lung collagen, bronchoalveolar lavage cell counts, total protein, LPA, and TGF-β levels, attenuates the pathogenesis of pulmonary fibrosis in vivo.

Name	Disodium [4-(decanoylamino)benzyl]phosphonate
Synonyms	Phosphonic acid, [[4-[(1-oxodecyl)amino]phenyl]methyl]-, sodium salt (1:2) Disodium [4-(decanoylamino)benzyl]phosphonate

Description	GWJ-A-23 (GWJ-23, GWJ23) is a potent, selective autotaxin inhibitor with Ki of 18 nM, an analog of the known ATX inhibitor S32826 and has improved aqueous solubility compared with the parent compound; reduces lung collagen, bronchoalveolar lavage cell counts, total protein, LPA, and TGF-β levels, attenuates the pathogenesis of pulmonary fibrosis in vivo.
References	References 1. Jiang G, et al. Bioorg Med Chem Lett. 2011 Sep 1;21(17):5098-101. View Related Products by Target Autotaxin