GWJ-A-23

Modify Date: 2024-02-22 09:33:30

GWJ-A-23 Structure
GWJ-A-23 structure
Common Name GWJ-A-23
CAS Number 1351930-95-4 Molecular Weight 385.346
Density N/A Boiling Point N/A
Molecular Formula C17H28NO4P Melting Point N/A
MSDS N/A Flash Point N/A

 Use of GWJ-A-23


GWJ-A-23 (GWJ-23, GWJ23) is a potent, selective autotaxin inhibitor with Ki of 18 nM, an analog of the known ATX inhibitor S32826 and has improved aqueous solubility compared with the parent compound; reduces lung collagen, bronchoalveolar lavage cell counts, total protein, LPA, and TGF-β levels, attenuates the pathogenesis of pulmonary fibrosis in vivo.

 Names

Name Disodium [4-(decanoylamino)benzyl]phosphonate
Synonym More Synonyms

 GWJ-A-23 Biological Activity

Description GWJ-A-23 (GWJ-23, GWJ23) is a potent, selective autotaxin inhibitor with Ki of 18 nM, an analog of the known ATX inhibitor S32826 and has improved aqueous solubility compared with the parent compound; reduces lung collagen, bronchoalveolar lavage cell counts, total protein, LPA, and TGF-β levels, attenuates the pathogenesis of pulmonary fibrosis in vivo.
References References 1. Jiang G, et al. Bioorg Med Chem Lett. 2011 Sep 1;21(17):5098-101. View Related Products by Target Autotaxin

 Chemical & Physical Properties

Molecular Formula C17H28NO4P
Molecular Weight 385.346
Exact Mass 385.139496

 Synonyms

Phosphonic acid, [[4-[(1-oxodecyl)amino]phenyl]methyl]-, sodium salt (1:2)
Disodium [4-(decanoylamino)benzyl]phosphonate