1352064-70-0
1352064-70-0 structure
- Name: AM-8553
- Chemical Name: AM-8553
- CAS Number: 1352064-70-0
- Molecular Formula: C25H29Cl2NO4
- Molecular Weight: 478.408
- Catalog: Signaling Pathways Apoptosis MDM-2/p53
- Create Date: 2020-01-11 15:34:50
- Modify Date: 2024-04-05 16:27:52
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A potent, selective, orally bioavailable MDM2-p53 interaction inhibitor with HTRF IC50 of 1.1 nM, SJSA-1 EdU IC50 of 68 nM; exhibits excellent pharmacokinetic properties and in vivo efficacy.
| Name | AM-8553 |
|---|---|
| Synonyms |
{(3R,5R,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-1-[(2S,3S)-2-hydroxy-3-pentanyl]-3-methyl-2-oxo-3-piperidinyl}acetic acid
3-Piperidineacetic acid, 5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-[(1S,2S)-1-ethyl-2-hydroxypropyl]-3-methyl-2-oxo-, (3R,5R,6S)- AM-8553 {(3r,5r,6s)-5-(3-Chlorophenyl)-6-(4-Chlorophenyl)-1-[(2s,3s)-2-Hydroxypentan-3-Yl]-3-Methyl-2-Oxopiperidin-3-Yl}acetic Acid |
| Description | A potent, selective, orally bioavailable MDM2-p53 interaction inhibitor with HTRF IC50 of 1.1 nM, SJSA-1 EdU IC50 of 68 nM; exhibits excellent pharmacokinetic properties and in vivo efficacy. |
|---|---|
| References | References 1. Rew Y, et al. J Med Chem. 2012 Jun 14;55(11):4936-54. 2. Bernard D, et al. J Med Chem. 2012 Jun 14;55(11):4934-5. 3. Lucas BS, et al. J Am Chem Soc. 2012 Aug 1;134(30):12855-60. View Related Products by Target MDM2-p53 |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 644.0±55.0 °C at 760 mmHg |
| Molecular Formula | C25H29Cl2NO4 |
| Molecular Weight | 478.408 |
| Flash Point | 343.3±31.5 °C |
| Exact Mass | 477.147369 |
| LogP | 5.40 |
| Vapour Pressure | 0.0±2.0 mmHg at 25°C |
| Index of Refraction | 1.575 |