1360821-61-9
1360821-61-9 structure
- Name: RO-5353
- Chemical Name: (2S,3R,4R,5R)-N-(4-Carbamoyl-2-methoxyphenyl)-2'-chloro-4-(3-chloro-2-fluorophenyl)-2-(2,2-dimethylpropyl)-5'-oxo-4',5'-dihydrospiro[pyrrolidine-3,6'-thieno[3,2-b]pyrrole]-5-carboxamide
- CAS Number: 1360821-61-9
- Molecular Formula: C29H29Cl2FN4O4S
- Molecular Weight: 619.534
- Create Date: 2020-01-11 19:21:50
- Modify Date: 2024-02-07 08:56:16
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A potent, selective, and orally active p53-MDM2 antagonist with IC50 of 7 nM; exhibits substantial cellular antiproliferative potency/selectivity and comparse favorably to RO8994; displays tumor regression in tumor models at 10 mg/kg.
| Name | (2S,3R,4R,5R)-N-(4-Carbamoyl-2-methoxyphenyl)-2'-chloro-4-(3-chloro-2-fluorophenyl)-2-(2,2-dimethylpropyl)-5'-oxo-4',5'-dihydrospiro[pyrrolidine-3,6'-thieno[3,2-b]pyrrole]-5-carboxamide |
|---|---|
| Synonyms |
Spiro[pyrrolidine-3,6'-[6H]thieno[3,2-b]pyrrole]-5-carboxamide, N-[4-(aminocarbonyl)-2-methoxyphenyl]-2'-chloro-4-(3-chloro-2-fluorophenyl)-2-(2,2-dimethylpropyl)-4',5'-dihydro-5'-oxo-, (2S,3R,4R,5R)-
(2S,3R,4R,5R)-N-(4-Carbamoyl-2-methoxyphenyl)-2'-chloro-4-(3-chloro-2-fluorophenyl)-2-(2,2-dimethylpropyl)-5'-oxo-4',5'-dihydrospiro[pyrrolidine-3,6'-thieno[3,2-b]pyrrole]-5-carboxamide |
| Description | A potent, selective, and orally active p53-MDM2 antagonist with IC50 of 7 nM; exhibits substantial cellular antiproliferative potency/selectivity and comparse favorably to RO8994; displays tumor regression in tumor models at 10 mg/kg. |
|---|---|
| References | References 1. Zhang Z, et al. ACS Med Chem Lett. 2013 Dec 29;5(2):124-7. View Related Products by Target MDM2-p53 |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 759.1±60.0 °C at 760 mmHg |
| Molecular Formula | C29H29Cl2FN4O4S |
| Molecular Weight | 619.534 |
| Flash Point | 412.9±32.9 °C |
| Exact Mass | 618.127075 |
| LogP | 6.32 |
| Vapour Pressure | 0.0±2.6 mmHg at 25°C |
| Index of Refraction | 1.663 |