143816-42-6

143816-42-6 structure

Name: Quininib
Chemical Name: Quininib
CAS Number: 143816-42-6
Molecular Formula: C₁₇H₁₃NO
Molecular Weight: 247.291
Catalog: Signaling Pathways GPCR/G Protein Leukotriene Receptor
Create Date: 2020-01-11 12:39:58
Modify Date: 2024-07-06 06:35:27
A potent inhibitor of developmental angiogenesis in the zebrafish eye, and a cysteinyl leukotriene 1 and 2 receptor (CysLT1 and 2) antaognist with IC50 of 1.2 and 52 uM, respectively; demonstrates significant anti-angiogenic activity in human endothelial cell, murine aortic ring, and murine oxygen-induced retinopathy models of angiogenesis; does not directly target VEGFRs, and inhibits angiogenesis in a range of cell and tissue systems.

Name	Quininib
Synonyms	2-[(E)-2-(2-Quinolinyl)vinyl]phenol Quininib 2-[(E)-2-(Quinolin-2-yl)vinyl]phenol 2-[(E)-2-(quinolin-2-yl)ethenyl]phenol Phenol, 2-[(E)-2-(2-quinolinyl)ethenyl]- (E)-2-[2-(2-Quinolinyl)ethenyl]-phenol MFCD00186931

Description	A potent inhibitor of developmental angiogenesis in the zebrafish eye, and a cysteinyl leukotriene 1 and 2 receptor (CysLT1 and 2) antaognist with IC50 of 1.2 and 52 uM, respectively; demonstrates significant anti-angiogenic activity in human endothelial cell, murine aortic ring, and murine oxygen-induced retinopathy models of angiogenesis; does not directly target VEGFRs, and inhibits angiogenesis in a range of cell and tissue systems.
References	References 1. Reynolds AL, et al. J Biol Chem. 2016 Apr 1;291(14):7242-55. 2. Murphy AG, et al. Sci Rep. 2016 Oct 14;6:34523. 3. Galvin O, et al. J Control Release. 2016 Jul 10;233:198-207. 4. Butler CT, et al. J Biol Chem. 2017 Mar 3;292(9):3552-3567. View Related Products by Target Leukotriene Receptor