Quininib
Modify Date: 2023-03-05 16:32:45
Quininib structure
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Common Name | Quininib | ||
|---|---|---|---|---|
| CAS Number | 143816-42-6 | Molecular Weight | 247.291 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 434.3±14.0 °C at 760 mmHg | |
| Molecular Formula | C17H13NO | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 216.5±20.1 °C | |
Use of QuininibA potent inhibitor of developmental angiogenesis in the zebrafish eye, and a cysteinyl leukotriene 1 and 2 receptor (CysLT1 and 2) antaognist with IC50 of 1.2 and 52 uM, respectively; demonstrates significant anti-angiogenic activity in human endothelial cell, murine aortic ring, and murine oxygen-induced retinopathy models of angiogenesis; does not directly target VEGFRs, and inhibits angiogenesis in a range of cell and tissue systems. |
| Name | Quininib |
|---|---|
| Synonym | More Synonyms |
| Description | A potent inhibitor of developmental angiogenesis in the zebrafish eye, and a cysteinyl leukotriene 1 and 2 receptor (CysLT1 and 2) antaognist with IC50 of 1.2 and 52 uM, respectively; demonstrates significant anti-angiogenic activity in human endothelial cell, murine aortic ring, and murine oxygen-induced retinopathy models of angiogenesis; does not directly target VEGFRs, and inhibits angiogenesis in a range of cell and tissue systems. |
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| References | References 1. Reynolds AL, et al. J Biol Chem. 2016 Apr 1;291(14):7242-55. 2. Murphy AG, et al. Sci Rep. 2016 Oct 14;6:34523. 3. Galvin O, et al. J Control Release. 2016 Jul 10;233:198-207. 4. Butler CT, et al. J Biol Chem. 2017 Mar 3;292(9):3552-3567. View Related Products by Target Leukotriene Receptor |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 434.3±14.0 °C at 760 mmHg |
| Molecular Formula | C17H13NO |
| Molecular Weight | 247.291 |
| Flash Point | 216.5±20.1 °C |
| Exact Mass | 247.099716 |
| LogP | 4.72 |
| Vapour Pressure | 0.0±1.1 mmHg at 25°C |
| Index of Refraction | 1.758 |
| 2-[(E)-2-(2-Quinolinyl)vinyl]phenol |
| Quininib |
| 2-[(E)-2-(Quinolin-2-yl)vinyl]phenol |
| 2-[(E)-2-(quinolin-2-yl)ethenyl]phenol |
| Phenol, 2-[(E)-2-(2-quinolinyl)ethenyl]- |
| (E)-2-[2-(2-Quinolinyl)ethenyl]-phenol |
| MFCD00186931 |