150661-91-9

150661-91-9 structure

Name: NC1153
Chemical Name: 2,12-Bis[(dimethylamino)methyl]cyclododecanone dihydrochloride
CAS Number: 150661-91-9
Molecular Formula: C₁₈H₃₈Cl₂N₂O
Molecular Weight: 369.413
Create Date: 2020-01-12 11:39:51
Modify Date: 2024-01-14 22:17:24
A Mannich base compound, selective and orally active JAK3 inhibitor that blocks IL-2-induced activation of JAK3 and downstream substrates STAT5a/b; fails to inhibit several other enzymes, including growth factor receptor tyrosine kinases, Src family members, and serine/threonine protein kinases; inhibits proliferation of normal human T cells challenged with IL-2, IL-4, or IL-7; significantly extends survival of MHC/non-MHC mismatched rat kidney allografts, induces transplantation tolerance in vivo.

Name	2,12-Bis[(dimethylamino)methyl]cyclododecanone dihydrochloride
Synonyms	2,12-Bis[(dimethylamino)methyl]cyclododecanone dihydrochloride Cyclododecanone, 2,12-bis[(dimethylamino)methyl]-, hydrochloride (1:2)

Description	A Mannich base compound, selective and orally active JAK3 inhibitor that blocks IL-2-induced activation of JAK3 and downstream substrates STAT5a/b; fails to inhibit several other enzymes, including growth factor receptor tyrosine kinases, Src family members, and serine/threonine protein kinases; inhibits proliferation of normal human T cells challenged with IL-2, IL-4, or IL-7; significantly extends survival of MHC/non-MHC mismatched rat kidney allografts, induces transplantation tolerance in vivo.
References	References 1. Stepkowski SM, et al. J Immunol. 2005 Oct 1;175(7):4236-46. 2. Nagy ZS, et al. Mol Cancer. 2009 Aug 26;8:67. 3. Nagy ZS, et al. FEBS Lett. 2010 Apr 16;584(8):1515-20. View Related Products by Target JAK