NC1153
Modify Date: 2024-01-14 22:17:24
NC1153 structure
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Common Name | NC1153 | ||
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| CAS Number | 150661-91-9 | Molecular Weight | 369.413 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C18H38Cl2N2O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of NC1153A Mannich base compound, selective and orally active JAK3 inhibitor that blocks IL-2-induced activation of JAK3 and downstream substrates STAT5a/b; fails to inhibit several other enzymes, including growth factor receptor tyrosine kinases, Src family members, and serine/threonine protein kinases; inhibits proliferation of normal human T cells challenged with IL-2, IL-4, or IL-7; significantly extends survival of MHC/non-MHC mismatched rat kidney allografts, induces transplantation tolerance in vivo. |
| Name | 2,12-Bis[(dimethylamino)methyl]cyclododecanone dihydrochloride |
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| Synonym | More Synonyms |
| Description | A Mannich base compound, selective and orally active JAK3 inhibitor that blocks IL-2-induced activation of JAK3 and downstream substrates STAT5a/b; fails to inhibit several other enzymes, including growth factor receptor tyrosine kinases, Src family members, and serine/threonine protein kinases; inhibits proliferation of normal human T cells challenged with IL-2, IL-4, or IL-7; significantly extends survival of MHC/non-MHC mismatched rat kidney allografts, induces transplantation tolerance in vivo. |
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| References | References 1. Stepkowski SM, et al. J Immunol. 2005 Oct 1;175(7):4236-46. 2. Nagy ZS, et al. Mol Cancer. 2009 Aug 26;8:67. 3. Nagy ZS, et al. FEBS Lett. 2010 Apr 16;584(8):1515-20. View Related Products by Target JAK |
| Molecular Formula | C18H38Cl2N2O |
|---|---|
| Molecular Weight | 369.413 |
| Exact Mass | 368.236115 |
| 2,12-Bis[(dimethylamino)methyl]cyclododecanone dihydrochloride |
| Cyclododecanone, 2,12-bis[(dimethylamino)methyl]-, hydrochloride (1:2) |