1596348-16-1
1596348-16-1 structure
- Name: KDM5-C49
- Chemical Name: KDM5-C49
- CAS Number: 1596348-16-1
- Molecular Formula: C15H24N4O3
- Molecular Weight: 308.376
- Catalog: Signaling Pathways Epigenetics Histone Demethylase
- Create Date: 2020-01-11 17:16:01
- Modify Date: 2024-04-03 11:42:55
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KDM5-C49 is a potent, selective KDM5 inhibitor with IC50 of 25, 30 and 59 nM for KDM5A, B and C, respectively; displays 25-100-fold selectivity over KDM6B, 2-30-fold selectivity over KDM4 family, but with less cell-permeablity.
| Name | KDM5-C49 |
|---|---|
| Synonyms |
4-Pyridinecarboxylic acid, 2-[[[2-[[2-(dimethylamino)ethyl]ethylamino]-2-oxoethyl]amino]methyl]-
6OQJ5L847C KDM5-C49 MFCD31539980 2-{[(2-{[2-(Dimethylamino)ethyl](ethyl)amino}-2-oxoethyl)amino]methyl}isonicotinic acid |
| Description | KDM5-C49 is a potent, selective KDM5 inhibitor with IC50 of 25, 30 and 59 nM for KDM5A, B and C, respectively; displays 25-100-fold selectivity over KDM6B, 2-30-fold selectivity over KDM4 family, but with less cell-permeablity. |
|---|---|
| References | References 1. Johansson C, et. Nat Chem Biol. 2016 Jul;12(7):539-45. 2. Horton JR, et al. Cell Chem Biol. 2016 Jul 21;23(7):769-81. View Related Products by Target Histone Demethylase |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 531.0±50.0 °C at 760 mmHg |
| Molecular Formula | C15H24N4O3 |
| Molecular Weight | 308.376 |
| Flash Point | 275.0±30.1 °C |
| Exact Mass | 308.184845 |
| LogP | -0.13 |
| Vapour Pressure | 0.0±1.5 mmHg at 25°C |
| Index of Refraction | 1.552 |