1611470-23-5

1611470-23-5 structure

Name: Mitochonic Acid 35
Chemical Name: {5-[(3,5-Dimethoxybenzyl)oxy]-1H-indol-3-yl}acetic acid
CAS Number: 1611470-23-5
Molecular Formula: C₁₉H₁₉NO₅
Molecular Weight: 341.358
Catalog: Research Areas Others
Create Date: 2020-01-11 13:30:55
Modify Date: 2023-10-17 23:14:41
A dual inhibitor of TNF-α and TGF-β1 by inhibiting IκB kinase phosphorylation and Smad3 phosphorylation; attenuates the LPS/GaIN-induced hepatic inflammation in the mice, and downregulates TGF-β1-induced fibrotic gene expression; attenuates renal inflammation and fibrosis with the downregulation of inflammatory cytokines and fibrotic gene expressions in renal fibrosis model.

Name	{5-[(3,5-Dimethoxybenzyl)oxy]-1H-indol-3-yl}acetic acid
Synonyms	{5-[(3,5-Dimethoxybenzyl)oxy]-1H-indol-3-yl}acetic acid 1H-Indole-3-acetic acid, 5-[(3,5-dimethoxyphenyl)methoxy]-

Description	A dual inhibitor of TNF-α and TGF-β1 by inhibiting IκB kinase phosphorylation and Smad3 phosphorylation; attenuates the LPS/GaIN-induced hepatic inflammation in the mice, and downregulates TGF-β1-induced fibrotic gene expression; attenuates renal inflammation and fibrosis with the downregulation of inflammatory cytokines and fibrotic gene expressions in renal fibrosis model.
References	References 1. Shima H, et al. Sci Rep. 2017 May 15;7(1):1884. View Related Products by Target TNF-alpha