169675-08-5
169675-08-5 structure
- Name: Ro 60-0175
- Chemical Name: 1-(6-chloro-5-fluoro-1-indolyl)-2-propanamine
- CAS Number: 169675-08-5
- Molecular Formula: C11H12ClFN2
- Molecular Weight: 226.678
- Catalog: Signaling Pathways GPCR/G Protein 5-HT Receptor
- Create Date: 2020-01-11 11:01:35
- Modify Date: 2024-01-18 17:49:32
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Ro 60-0175 is a potent, selective 5-HT2C receptor agonist with pKi of 9, 7.5, 5.4, 5.2 and 5.6 for human 5-HT2C, 2A, 1A, 6 and 7 receptors respectively; induces hypolocomotion in rats at doses greater than 0.5 mg/kg s.c.; (0.3 and 1 mg/kg s.c.) simultaneously reduces both unpunished and punished lever pressing, a profile consistent with sedation, induces sedative-like responses via 5-HT(2C) receptor activation in vivo.
| Name | 1-(6-chloro-5-fluoro-1-indolyl)-2-propanamine |
|---|---|
| Synonyms |
1H-Indole-1-ethanamine, 6-chloro-5-fluoro-α-methyl-
1-(6-Chloro-5-fluoro-1H-indol-1-yl)-2-propanamine 1-(6-chloro-5-fluoro-1H-indol-1-yl)propan-2-amine 1-(6-chloro-5-fluoro-1-indolyl)-2-propanamine |
| Description | Ro 60-0175 is a potent, selective 5-HT2C receptor agonist with pKi of 9, 7.5, 5.4, 5.2 and 5.6 for human 5-HT2C, 2A, 1A, 6 and 7 receptors respectively; induces hypolocomotion in rats at doses greater than 0.5 mg/kg s.c.; (0.3 and 1 mg/kg s.c.) simultaneously reduces both unpunished and punished lever pressing, a profile consistent with sedation, induces sedative-like responses via 5-HT(2C) receptor activation in vivo. |
|---|---|
| References | References 1. Damjanoska KJ, et al. J Pharmacol Exp Ther. 2003 Mar;304(3):1209-16. 2. Vickers SP, et al. Br J Pharmacol. 2000 Jul;130(6):1305-14. 3. Kennett G, et al. Eur J Pharmacol. 2000 Jan 10;387(2):197-204. 4. Jenck F, et al. Eur Neuropsychopharmacol. 1998 Aug;8(3):161-8. View Related Products by Target 5-HT Receptor |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 353.2±32.0 °C at 760 mmHg |
| Molecular Formula | C11H12ClFN2 |
| Molecular Weight | 226.678 |
| Flash Point | 167.4±25.1 °C |
| Exact Mass | 226.067307 |
| LogP | 3.00 |
| Vapour Pressure | 0.0±0.8 mmHg at 25°C |
| Index of Refraction | 1.595 |