1854061-19-0
1854061-19-0 structure
- Name: PF-06761281
- Chemical Name: PF-06761281
- CAS Number: 1854061-19-0
- Molecular Formula: C13H17NO6
- Molecular Weight: 283.277
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel Sodium Channel
- Create Date: 2020-01-11 20:04:32
- Modify Date: 2024-01-04 12:44:02
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A potent, selective sodium-coupled citrate transporter (NaCT or SLC13A5) with IC50 of 0.51 uM, >20-fold selectivity over NaDC1 and NaDC3; demonstrates dose-dependent inhibition of radioactive [(14)C]citrate uptake in liver and kidney in vivo, reduces fasting plasma glucose concentrations with suitable in vivo pharmacokinetic profile.
| Name | PF-06761281 |
|---|---|
| Synonyms |
(2R)-2-Hydroxy-2-[2-(2-methoxy-5-methyl-3-pyridinyl)ethyl]succinic acid
PF-06761281 (R)-2-Hydroxy-2-(2-(2-methoxy-5-methylpyridin-3-yl)ethyl)-succinic acid (2R)-2-Hydroxy-2-[2-(2-methoxy-5-methyl-3-pyridinyl)ethyl]-butanedioic acid Butanedioic acid, 2-hydroxy-2-[2-(2-methoxy-5-methyl-3-pyridinyl)ethyl]-, (2R)- MFCD30187578 |
| Description | A potent, selective sodium-coupled citrate transporter (NaCT or SLC13A5) with IC50 of 0.51 uM, >20-fold selectivity over NaDC1 and NaDC3; demonstrates dose-dependent inhibition of radioactive [(14)C]citrate uptake in liver and kidney in vivo, reduces fasting plasma glucose concentrations with suitable in vivo pharmacokinetic profile. |
|---|---|
| References | References 1. Huard K, et al. J Med Chem. 2016 Feb 11;59(3):1165-75. 2. Rives ML, et al. Mol Pharmacol. 2016 Dec;90(6):766-774. View Related Products by Target Sodium-coupled Citrate Transporter (NaCT,SLC13A5) |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 469.7±45.0 °C at 760 mmHg |
| Molecular Formula | C13H17NO6 |
| Molecular Weight | 283.277 |
| Flash Point | 237.9±28.7 °C |
| Exact Mass | 283.105591 |
| LogP | 0.97 |
| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
| Index of Refraction | 1.571 |
| Storage condition | 20°C |
| Hazard Codes | T |
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