2016806-57-6
2016806-57-6 structure
- Name: AZ 13705339
- Chemical Name: 2-({(2-{[3-(Ethylsulfonyl)-4-(4-methyl-1-piperazinyl)phenyl]amino}-5-fluoro-4-pyrimidinyl)[5-(hydroxymethyl)-2-methylphenyl]amino}methyl)benzonitrile
- CAS Number: 2016806-57-6
- Molecular Formula: C33H36FN7O3S
- Molecular Weight: 629.747
- Catalog: Signaling Pathways Cell Cycle/DNA Damage PAK
- Create Date: 2020-01-12 12:13:49
- Modify Date: 2025-08-25 11:27:07
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AZ13705339 is a potent, selective PAK1 inhibitor with IC50 of 0.33 nM, displays 14-, 470-, 4100- and 2600-fold selectivity over Src, FGFR1, KDR and PAK4; inhibits cellular pPAK1 inhibition in MCF10A cell line with IC50 of 59 nM.
| Name | 2-({(2-{[3-(Ethylsulfonyl)-4-(4-methyl-1-piperazinyl)phenyl]amino}-5-fluoro-4-pyrimidinyl)[5-(hydroxymethyl)-2-methylphenyl]amino}methyl)benzonitrile |
|---|---|
| Synonyms |
Benzonitrile, 2-[[[2-[[3-(ethylsulfonyl)-4-(4-methyl-1-piperazinyl)phenyl]amino]-5-fluoro-4-pyrimidinyl][5-(hydroxymethyl)-2-methylphenyl]amino]methyl]-
2-({(2-{[3-(Ethylsulfonyl)-4-(4-methyl-1-piperazinyl)phenyl]amino}-5-fluoro-4-pyrimidinyl)[5-(hydroxymethyl)-2-methylphenyl]amino}methyl)benzonitrile |
| Description | AZ13705339 is a potent, selective PAK1 inhibitor with IC50 of 0.33 nM, displays 14-, 470-, 4100- and 2600-fold selectivity over Src, FGFR1, KDR and PAK4; inhibits cellular pPAK1 inhibition in MCF10A cell line with IC50 of 59 nM. |
|---|---|
| References | References 1. McCoull W, et al. ACS Med Chem Lett. 2016 Sep 14;7(12):1118-1123. View Related Products by Target p21-activated Kinase (PAK) |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 868.7±75.0 °C at 760 mmHg |
| Molecular Formula | C33H36FN7O3S |
| Molecular Weight | 629.747 |
| Flash Point | 479.2±37.1 °C |
| Exact Mass | 629.258423 |
| LogP | 1.96 |
| Vapour Pressure | 0.0±0.3 mmHg at 25°C |
| Index of Refraction | 1.682 |