218929-99-8
218929-99-8 structure
- Name: IMM-02
- Chemical Name: (2E)-2-[1-(3,5-Difluoro-2-hydroxyphenyl)ethylidene]-1-(2-methyl-2-propanyl)hydrazinecarbothioamide
- CAS Number: 218929-99-8
- Molecular Formula: C13H17F2N3OS
- Molecular Weight: 301.355
- Create Date: 2020-01-11 20:09:57
- Modify Date: 2024-01-13 08:23:26
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IMM-02 is a small molecule agonist of mammalian Diaphanous (mDia)-related formins that disrupts diaphanous inhibitory domain (DID) and diaphanous autoregulatory domain (DAD) interaction with IC50 of 99 nM; sufficiently triggers actin assembly and microtubule stabilization, serum response factor-mediated gene expression, cell-cycle arrest, and apoptosis in vitro; slows tumor growth in a mouse xenograft model of colon cancer.
| Name | (2E)-2-[1-(3,5-Difluoro-2-hydroxyphenyl)ethylidene]-1-(2-methyl-2-propanyl)hydrazinecarbothioamide |
|---|---|
| Synonyms |
Hydrazinecarbothioamide, 2-[1-(3,5-difluoro-2-hydroxyphenyl)ethylidene]-1-(1,1-dimethylethyl)-, (2E)-
(2E)-2-[1-(3,5-Difluoro-2-hydroxyphenyl)ethylidene]-1-(2-methyl-2-propanyl)hydrazinecarbothioamide |
| Description | IMM-02 is a small molecule agonist of mammalian Diaphanous (mDia)-related formins that disrupts diaphanous inhibitory domain (DID) and diaphanous autoregulatory domain (DAD) interaction with IC50 of 99 nM; sufficiently triggers actin assembly and microtubule stabilization, serum response factor-mediated gene expression, cell-cycle arrest, and apoptosis in vitro; slows tumor growth in a mouse xenograft model of colon cancer. |
|---|---|
| References | References 1. Lash LL, et al. Cancer Res. 2013 Nov 15;73(22):6793-803. 2. Arden JD, et al. Mol Biol Cell. 2015 Nov 1;26(21):3704-18. View Related Products by Target Other Targets |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 390.4±52.0 °C at 760 mmHg |
| Molecular Formula | C13H17F2N3OS |
| Molecular Weight | 301.355 |
| Flash Point | 189.9±30.7 °C |
| Exact Mass | 301.106049 |
| LogP | 3.73 |
| Vapour Pressure | 0.0±0.9 mmHg at 25°C |
| Index of Refraction | 1.552 |