349093-44-3
349093-44-3 structure
- Name: PTGR2-IN-1
- Chemical Name: 1-[4-(2-Methoxyphenyl)-1-piperazinyl]-2-phenylethanone
- CAS Number: 349093-44-3
- Molecular Formula: C19H22N2O2
- Molecular Weight: 310.390
- Catalog: Research Areas Others
- Create Date: 2020-01-11 19:43:00
- Modify Date: 2024-09-21 08:03:38
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PTGR2-IN-1 is a potent PTGR2 inhibitor with an IC50 of ~0.7 μM. PTGR2-IN-1 increases 15-keto-PGE2-dependent PPARγ transcriptional activity in PTGR2-transfected HEK293T cells[1].
| Name | 1-[4-(2-Methoxyphenyl)-1-piperazinyl]-2-phenylethanone |
|---|---|
| Synonyms |
Ethanone, 1-[4-(2-methoxyphenyl)-1-piperazinyl]-2-phenyl-
1-[4-(2-Methoxyphenyl)-1-piperazinyl]-2-phenylethanone |
| Description | PTGR2-IN-1 is a potent PTGR2 inhibitor with an IC50 of ~0.7 μM. PTGR2-IN-1 increases 15-keto-PGE2-dependent PPARγ transcriptional activity in PTGR2-transfected HEK293T cells[1]. |
|---|---|
| Related Catalog | |
| In Vitro | A screen of structural analogs of 20 identified PTGR2-IN-1, which shows substantially increased potency (>20-fold) in assays measuring either competition of 8-labeling or 15-keto-PGE2 reductase activity (IC50 = 0.6 μM) of recombinant PTGR2, as well as an inactive control compound 23. PTGR2-IN-1 (Compound 22) blocks FFF 8 labeling of endogenous PTGR2 in HEK293T cells with good potency (complete inhibition at 5 μM and ~80% inhibition at 500 nM) and excellent selectivity[1]. |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 512.9±50.0 °C at 760 mmHg |
| Molecular Formula | C19H22N2O2 |
| Molecular Weight | 310.390 |
| Flash Point | 264.0±30.1 °C |
| Exact Mass | 310.168121 |
| LogP | 2.65 |
| Vapour Pressure | 0.0±1.3 mmHg at 25°C |
| Index of Refraction | 1.588 |
| Storage condition | -20°C |
| Hazard Codes | Xn |
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