439946-22-2
439946-22-2 structure
- Name: LDN 91946
- Chemical Name: LDN-91946
- CAS Number: 439946-22-2
- Molecular Formula: C17H12N6O
- Molecular Weight: 314.316
- Catalog: Signaling Pathways Cell Cycle/DNA Damage Deubiquitinase
- Create Date: 2020-01-12 06:47:53
- Modify Date: 2024-01-10 17:27:35
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LDN 91946 is a selective, uncompetitive ubiquitin C-terminal hydrolase-L1 (UCH-L1) inhibitor with Ki of 2.8 uM, exhibits no activity against other cysteine hydrolase (UCH-L3, TGase 2, papain and caspase-3).
| Name | LDN-91946 |
|---|---|
| Synonyms |
3-Amino-2-benzoyl-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carboxylic acid
Thieno[2,3-b]pyridine-5-carboxylic acid, 3-amino-2-benzoyl-6,7-dihydro-6-oxo- LDN-91946 MFCD03016619 |
| Description | LDN 91946 is a selective, uncompetitive ubiquitin C-terminal hydrolase-L1 (UCH-L1) inhibitor with Ki of 2.8 uM, exhibits no activity against other cysteine hydrolase (UCH-L3, TGase 2, papain and caspase-3). |
|---|---|
| References | References 1. Mermerian AH, et al. Bioorg Med Chem Lett. 2007 Jul 1;17(13):3729-32. 2. Coulombe J, et al. Front Aging Neurosci. 2014 Jun 19;6:129. View Related Products by Target Deubiquitinase (DUB) |
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Boiling Point | 714.0±60.0 °C at 760 mmHg |
| Molecular Formula | C17H12N6O |
| Molecular Weight | 314.316 |
| Flash Point | 385.6±32.9 °C |
| Exact Mass | 314.036133 |
| LogP | 2.20 |
| Vapour Pressure | 0.0±2.4 mmHg at 25°C |
| Index of Refraction | 1.722 |