50405-58-8
50405-58-8 structure
- Name: TC-E 5008
- Chemical Name: SYC-435
- CAS Number: 50405-58-8
- Molecular Formula: C13H13NO2
- Molecular Weight: 215.248
- Catalog: Signaling Pathways Metabolic Enzyme/Protease Isocitrate Dehydrogenase (IDH)
- Create Date: 2020-01-11 17:59:53
- Modify Date: 2024-09-11 23:59:37
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SYC-435 (SYC435) is a potent inhibitor of mutant IDH1, binds at the isocitrate pocket of mutated IDH1 with Ki values of 190 nM against IDH1 R132H and 120 nM against IDH1 R132C; SYC-435 is cell active and capable of significantly reducing D-2-HG production in an HT1080 fibrosarcoma cell line expressing IDH1 R132C (IC50=2.4 uM).
| Name | SYC-435 |
|---|---|
| Synonyms |
6-benzyl-1-hydroxy-4-methylpyridin-2(1H)-one
6-Benzyl-1-hydroxy-4-methyl-2(1H)-pyridinone 2(1H)-Pyridinone, 1-hydroxy-4-methyl-6-(phenylmethyl)- SYC-435 |
| Description | SYC-435 (SYC435) is a potent inhibitor of mutant IDH1, binds at the isocitrate pocket of mutated IDH1 with Ki values of 190 nM against IDH1 R132H and 120 nM against IDH1 R132C; SYC-435 is cell active and capable of significantly reducing D-2-HG production in an HT1080 fibrosarcoma cell line expressing IDH1 R132C (IC50=2.4 uM). |
|---|---|
| References | References 1. Liu Z, et al. J Med Chem. 2014 Oct 23;57(20):8307-18. 2. Ma T, et al. J Med Chem. 2018 Jun 18. doi: 10.1021/acs.jmedchem.8b00159. View Related Products by Target Isocitrate Dehydrogenase (IDH) |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 384.0±35.0 °C at 760 mmHg |
| Molecular Formula | C13H13NO2 |
| Molecular Weight | 215.248 |
| Flash Point | 186.0±25.9 °C |
| Exact Mass | 215.094635 |
| LogP | 2.18 |
| Vapour Pressure | 0.0±0.9 mmHg at 25°C |
| Index of Refraction | 1.634 |