612514-42-8
612514-42-8 structure
- Name: VU0152099
- Chemical Name: VU0152099
- CAS Number: 612514-42-8
- Molecular Formula: C18H17N3O3S
- Molecular Weight: 355.411
- Catalog: Signaling Pathways GPCR/G Protein mAChR
- Create Date: 2020-01-11 09:39:54
- Modify Date: 2025-08-25 12:06:49
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VU0152099 is a potent, selective, CNS-penetrant positive allosteric modulator of M4 mAChR with EC50 of 403 nM; shows no agonist activity but potentiates responses of M(4) to acetylcholine, and is devoid of activity at other mAChR subtypes or at a panel of other GPCRs; reverses amphetamine-induced hyperlocomotion in rats.
| Name | VU0152099 |
|---|---|
| Synonyms |
3-Amino-N-(1,3-benzodioxol-5-ylmethyl)-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide
Thieno[2,3-b]pyridine-2-carboxamide, 3-amino-N-(1,3-benzodioxol-5-ylmethyl)-4,6-dimethyl- VU0152099 |
| Description | VU0152099 is a potent, selective, CNS-penetrant positive allosteric modulator of M4 mAChR with EC50 of 403 nM; shows no agonist activity but potentiates responses of M(4) to acetylcholine, and is devoid of activity at other mAChR subtypes or at a panel of other GPCRs; reverses amphetamine-induced hyperlocomotion in rats. |
|---|---|
| References | References 1. Brady AE, et al. J Pharmacol Exp Ther. 2008 Dec;327(3):941-53. View Related Products by Target mAChR |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 622.9±55.0 °C at 760 mmHg |
| Molecular Formula | C18H17N3O3S |
| Molecular Weight | 355.411 |
| Flash Point | 330.5±31.5 °C |
| Exact Mass | 355.099060 |
| LogP | 4.32 |
| Vapour Pressure | 0.0±1.8 mmHg at 25°C |
| Index of Refraction | 1.708 |