VU0152099

Modify Date: 2024-04-05 09:52:49

VU0152099 Structure
VU0152099 structure
Common Name VU0152099
CAS Number 612514-42-8 Molecular Weight 355.411
Density 1.4±0.1 g/cm3 Boiling Point 622.9±55.0 °C at 760 mmHg
Molecular Formula C18H17N3O3S Melting Point N/A
MSDS N/A Flash Point 330.5±31.5 °C

 Use of VU0152099


VU0152099 is a potent, selective, CNS-penetrant positive allosteric modulator of M4 mAChR with EC50 of 403 nM; shows no agonist activity but potentiates responses of M(4) to acetylcholine, and is devoid of activity at other mAChR subtypes or at a panel of other GPCRs; reverses amphetamine-induced hyperlocomotion in rats.

 Names

Name VU0152099
Synonym More Synonyms

 VU0152099 Biological Activity

Description VU0152099 is a potent, selective, CNS-penetrant positive allosteric modulator of M4 mAChR with EC50 of 403 nM; shows no agonist activity but potentiates responses of M(4) to acetylcholine, and is devoid of activity at other mAChR subtypes or at a panel of other GPCRs; reverses amphetamine-induced hyperlocomotion in rats.
References References 1. Brady AE, et al. J Pharmacol Exp Ther. 2008 Dec;327(3):941-53. View Related Products by Target mAChR

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 622.9±55.0 °C at 760 mmHg
Molecular Formula C18H17N3O3S
Molecular Weight 355.411
Flash Point 330.5±31.5 °C
Exact Mass 355.099060
LogP 4.32
Vapour Pressure 0.0±1.8 mmHg at 25°C
Index of Refraction 1.708

 Synonyms

3-Amino-N-(1,3-benzodioxol-5-ylmethyl)-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide
Thieno[2,3-b]pyridine-2-carboxamide, 3-amino-N-(1,3-benzodioxol-5-ylmethyl)-4,6-dimethyl-
VU0152099