642008-81-9
642008-81-9 structure
- Name: BRD 6989
- Chemical Name: 2-Amino-6-methyl-4-(3-pyridinyl)-5,6,7,8-tetrahydro-3-quinolinecarbonitrile
- CAS Number: 642008-81-9
- Molecular Formula: C16H16N4
- Molecular Weight: 264.325
- Catalog: Signaling Pathways Cell Cycle/DNA Damage CDK
- Create Date: 2020-01-11 13:16:54
- Modify Date: 2024-01-14 11:19:30
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A novel potent, selective CDK8 inhibitor with IC50 of 0.5 uM against recombinant Cyclin C/CDK8 complex; displays no activity against several CDKs involved in cell cycle including CDK19 (IC50>30 uM); inhibits IFNγ-induced phosphorylation of STAT1 at Ser 727 site in BMDCs, selectively upregulates IL-10 with EC50 of 1 uM.
| Name | 2-Amino-6-methyl-4-(3-pyridinyl)-5,6,7,8-tetrahydro-3-quinolinecarbonitrile |
|---|---|
| Synonyms |
3-Quinolinecarbonitrile, 2-amino-5,6,7,8-tetrahydro-6-methyl-4-(3-pyridinyl)-
2-Amino-6-methyl-4-(3-pyridinyl)-5,6,7,8-tetrahydro-3-quinolinecarbonitrile MFCD04013193 |
| Description | A novel potent, selective CDK8 inhibitor with IC50 of 0.5 uM against recombinant Cyclin C/CDK8 complex; displays no activity against several CDKs involved in cell cycle including CDK19 (IC50>30 uM); inhibits IFNγ-induced phosphorylation of STAT1 at Ser 727 site in BMDCs, selectively upregulates IL-10 with EC50 of 1 uM. |
|---|---|
| References | References 1. Johannessen L, et al. Nat Chem Biol. 2017 Oct;13(10):1102-1108. View Related Products by Target Cyclin-dependent Kinase (CDK) |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 496.6±45.0 °C at 760 mmHg |
| Molecular Formula | C16H16N4 |
| Molecular Weight | 264.325 |
| Flash Point | 254.2±28.7 °C |
| Exact Mass | 264.137512 |
| LogP | 3.69 |
| Vapour Pressure | 0.0±1.3 mmHg at 25°C |
| Index of Refraction | 1.640 |