65004-42-4
65004-42-4 structure
- Name: Pyrimidinone 8
- Chemical Name: 2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-methylpyrimidin-4-ol
- CAS Number: 65004-42-4
- Molecular Formula: C10H12N4O
- Molecular Weight: 204.229
- Create Date: 2020-01-11 12:21:55
- Modify Date: 2025-08-25 22:53:25
-
Pyrimidinone 8 is a novel allosteric, non-competitive divalent metal transporter-1 (SLC11A2/DMT1) inhibitor with Ki of 20 uM; does not affect hDMT1 cell surface expression and shows no dependence on extracellular pH.
| Name | 2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-methylpyrimidin-4-ol |
|---|---|
| Synonyms |
4(1H)-Pyrimidinone, 2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-methyl-
4(3H)-pyrimidinone, 2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-methyl- MFCD01416214 2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-methylpyrimidin-4(3H)-one 2-(3,5-Dimethyl-1H-pyrazol-1-yl)-6-methyl-4(1H)-pyrimidinone MFCD00097142 2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-methylpyrimidin-4-ol |
| Description | Pyrimidinone 8 is a novel allosteric, non-competitive divalent metal transporter-1 (SLC11A2/DMT1) inhibitor with Ki of 20 uM; does not affect hDMT1 cell surface expression and shows no dependence on extracellular pH. |
|---|---|
| References | References 1. Montalbetti N, et al. Biochem Pharmacol. 2015 Aug 1;96(3):216-24. View Related Products by Target Other Targets |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 410.4±48.0 °C at 760 mmHg |
| Molecular Formula | C10H12N4O |
| Molecular Weight | 204.229 |
| Flash Point | 202.0±29.6 °C |
| Exact Mass | 204.101105 |
| LogP | 1.28 |
| Vapour Pressure | 0.0±1.0 mmHg at 25°C |
| Index of Refraction | 1.650 |