713121-80-3

713121-80-3 structure

Name: ML 193
Chemical Name: N-[4-[(3,4-dimethyl-5-isoxazolyl)sulfamoyl]phenyl]-6,8-dimethyl-2-(2-pyridinyl)-4-quinolinecarboxamide
CAS Number: 713121-80-3
Molecular Formula: C₂₈H₂₅N₅O₄S
Molecular Weight: 527.594
Catalog: Signaling Pathways GPCR/G Protein GPR55
Create Date: 2020-01-20 18:14:55
Modify Date: 2024-04-04 18:26:17
ML193 (CID 1261822) is a potent, selective GPR55 antagonist with IC50 of 221 nM, shows >27-, >145- and >145-fold selectivity for GPR55 over CB1, GPR35 and CB2, respectively; reduces neuronal differentiation in vitro, increases anxiety-like behaviors while causing locomotor impairment by i.c.v. injection at the doses of 0.1 and 1 μg/rat.

Name	N-[4-[(3,4-dimethyl-5-isoxazolyl)sulfamoyl]phenyl]-6,8-dimethyl-2-(2-pyridinyl)-4-quinolinecarboxamide
Synonyms	4-Quinolinecarboxamide, N-[4-[[(3,4-dimethyl-5-isoxazolyl)amino]sulfonyl]phenyl]-6,8-dimethyl-2-(2-pyridinyl)- N-{4-[(3,4-Dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl}-6,8-dimethyl-2-(2-pyridinyl)-4-quinolinecarboxamide N-[4-[(3,4-dimethyl-5-isoxazolyl)sulfamoyl]phenyl]-6,8-dimethyl-2-(2-pyridinyl)-4-quinolinecarboxamide MFCD05999971

Description	ML193 (CID 1261822) is a potent, selective GPR55 antagonist with IC50 of 221 nM, shows >27-, >145- and >145-fold selectivity for GPR55 over CB1, GPR35 and CB2, respectively; reduces neuronal differentiation in vitro, increases anxiety-like behaviors while causing locomotor impairment by i.c.v. injection at the doses of 0.1 and 1 μg/rat.
References	References 1. Kotsikorou E, et al. Biochemistry. 2013 Dec 31;52(52):9456-69. 2. Munawar N, et al. Front Pharmacol. 2017 Mar 20;8:136. 3. Drzazga A, et al. Biochem Biophys Res Commun. 2017 Jul 22;489(2):242-247. 4. Hill JD, et al. Br J Pharmacol. 2018 Jun 11. doi: 10.1111/bph.14387. View Related Products by Target GPR55