ML 193
Modify Date: 2024-04-04 18:26:17
ML 193 structure
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Common Name | ML 193 | ||
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| CAS Number | 713121-80-3 | Molecular Weight | 527.594 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C28H25N5O4S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of ML 193ML193 (CID 1261822) is a potent, selective GPR55 antagonist with IC50 of 221 nM, shows >27-, >145- and >145-fold selectivity for GPR55 over CB1, GPR35 and CB2, respectively; reduces neuronal differentiation in vitro, increases anxiety-like behaviors while causing locomotor impairment by i.c.v. injection at the doses of 0.1 and 1 μg/rat. |
| Name | N-[4-[(3,4-dimethyl-5-isoxazolyl)sulfamoyl]phenyl]-6,8-dimethyl-2-(2-pyridinyl)-4-quinolinecarboxamide |
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| Synonym | More Synonyms |
| Description | ML193 (CID 1261822) is a potent, selective GPR55 antagonist with IC50 of 221 nM, shows >27-, >145- and >145-fold selectivity for GPR55 over CB1, GPR35 and CB2, respectively; reduces neuronal differentiation in vitro, increases anxiety-like behaviors while causing locomotor impairment by i.c.v. injection at the doses of 0.1 and 1 μg/rat. |
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| References | References 1. Kotsikorou E, et al. Biochemistry. 2013 Dec 31;52(52):9456-69. 2. Munawar N, et al. Front Pharmacol. 2017 Mar 20;8:136. 3. Drzazga A, et al. Biochem Biophys Res Commun. 2017 Jul 22;489(2):242-247. 4. Hill JD, et al. Br J Pharmacol. 2018 Jun 11. doi: 10.1111/bph.14387. View Related Products by Target GPR55 |
| Density | 1.4±0.1 g/cm3 |
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| Molecular Formula | C28H25N5O4S |
| Molecular Weight | 527.594 |
| Exact Mass | 527.162720 |
| LogP | 4.63 |
| Index of Refraction | 1.670 |
| Storage condition | -20°C |
| 4-Quinolinecarboxamide, N-[4-[[(3,4-dimethyl-5-isoxazolyl)amino]sulfonyl]phenyl]-6,8-dimethyl-2-(2-pyridinyl)- |
| N-{4-[(3,4-Dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl}-6,8-dimethyl-2-(2-pyridinyl)-4-quinolinecarboxamide |
| N-[4-[(3,4-dimethyl-5-isoxazolyl)sulfamoyl]phenyl]-6,8-dimethyl-2-(2-pyridinyl)-4-quinolinecarboxamide |
| MFCD05999971 |